{"id":35421,"date":"2024-02-26T17:50:00","date_gmt":"2024-02-26T08:50:00","guid":{"rendered":"https:\/\/uppthera.cafe24.com\/?p=35421"},"modified":"2024-02-26T17:50:00","modified_gmt":"2024-02-26T08:50:00","slug":"%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-%ec%9c%a0%ed%95%9c%ec%96%91%ed%96%89%ea%b3%bc-%ec%97%bc%ec%a6%9d%ec%9c%a0%eb%b0%9c-%eb%8b%a8%eb%b0%b1%ec%a7%88-%eb%b6%84%ed%95%b4","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2024\/02\/26\/%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-%ec%9c%a0%ed%95%9c%ec%96%91%ed%96%89%ea%b3%bc-%ec%97%bc%ec%a6%9d%ec%9c%a0%eb%b0%9c-%eb%8b%a8%eb%b0%b1%ec%a7%88-%eb%b6%84%ed%95%b4\/","title":{"rendered":"[\ubcf4\ub3c4 \uc790\ub8cc] \uc5c5\ud14c\ub77c, \uc720\ud55c\uc591\ud589\uacfc \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d\uc5d0 \ub300\ud55c \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uacc4\uc57d \uccb4\uacb0"},"content":{"rendered":"<p>\uc5c5\ud14c\ub77c (UPPTHERA)\ub294 \uc720\ud55c\uc591\ud589\uacfc \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uacc4\uc57d\uc744 \ub9fa\uace0, PROTAC Proteolysis Targeting Chimera, \ud45c\uc801\ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\uc220) \uae30\uc220\uc744 \uc774\uc6a9\ud55c \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uac1c\ubc1c\uc744 \uc9c4\ud589\ud55c\ub2e4\uace0 1\uc77c \ubc1d\ud614\ub2e4. \uc591\uc0ac\ub294 \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\ub97c \ud1b5\ud574 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ubc0f \uc5fc\uc99d\uc131 \uc9c8\ud658\uc744 \uce58\ub8cc\ud558\ub294 \uc2e0\uc57d\uc744 \uac1c\ubc1c\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c, \uc5c5\ud14c\ub77c\ub294 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c\uae4c\uc9c0 \uc8fc\ub3c4\uc801\uc778 \uc5f0\uad6c\uac1c\ubc1c\uc744 \uc9c4\ud589\ud558\uace0, \uc720\ud55c\uc591\ud589\uc740 \ube44\uc784\uc0c1 \uac1c\ubc1c\uc744 \ud3ec\ud568\ud55c \ud6c4\uc18d \uac1c\ubc1c \ubc0f \uc0ac\uc5c5\ud654\ub97c \uc804\ub2f4\ud558\ub294 \ud615\ud0dc\ub85c \ud611\uc5c5\ud560 \uc608\uc815\uc774\ub2e4. \uc5c5\ud14c\ub77c\ub294 \ubcf8 \uacc4\uc57d\uc744 \ud1b5\ud574 \uc720\ud55c\uc591\ud589\uc73c\ub85c\ubd80\ud130 \uacc4\uc57d\uae08\uc744 \ud3ec\ud568\ud558\uc5ec \ud2b9\uc815 \uc131\uacfc \ub2ec\uc131 \uc2dc \ub9c8\uc77c\uc2a4\ud1a4 \ubc0f \uacbd\uc0c1 \uae30\uc220\ub8cc\ub97c \uc218\ucde8\ud560 \uc608\uc815\uc774\uace0, \uc720\ud55c\uc591\ud589\uc774 \uc81c3\uc790\uc5d0\uac8c \ub77c\uc774\uc120\uc2a4 \uc544\uc6c3\uc744 \uc2e4\uc2dc\ud560 \uacbd\uc6b0 \uc218\uc775\uae08\uc758 \uc77c\ubd80\ub97c \ubc30\ubd84 \ubc1b\uac8c \ub41c\ub2e4. \uc720\ud55c\uc591\ud589\uc740 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c \uc774\ud6c4, \uc5f0\uad6c\uc131\uacfc\uc5d0 \ub300\ud55c \uc804\uc138\uacc4 \ub3c5\uc810\uc801 \uc804\uc6a9\uc2e4\uc2dc\uad8c\uc744 \ud655\ubcf4\ud558\uac8c \ub41c\ub2e4.<\/p>\n<p>\ud45c\uc801\ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\uc220\uc778 PROTAC \uc740 \uccb4\ub0b4 Ubiquitin Proteasome System (UPS)\uc744 \uc774\uc6a9\ud558\uc5ec \ud45c\uc801 \ud558\ub294 \uc9c8\ubcd1 \uc6d0\uc778 \ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \ubd84\ud574\ud558\ub294 \uae30\uc220\ub85c\uc11c, \ucc28\uc138\ub300 \uc2e0\uc57d\uac1c\ubc1c \ud50c\ub7ab\ud3fc\uc73c\ub85c\uc11c \ub300\ub450\ub418\uace0 \uc788\uc73c\uba70 \ud604\uc7ac \uad6d\ub0b4 \ub300\ud615 \uc81c\uc57d\uc0ac\ub4e4\ubfd0\ub9cc \uc544\ub2c8\ub77c Pfizer, Roche, Amgen\uacfc \uac19\uc740 \ub9ce\uc740 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uc774 \ub192\uc740 \uad00\uc2ec\uc744 \uac00\uc9c0\uace0 \uc801\uadf9\uc801\uc73c\ub85c \uc5f0\uad6c\uac1c\ubc1c \ubc0f \ud22c\uc790\ud558\uace0 \uc788\ub294 \uae30\uc220 \ubd84\uc57c\uc774\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 2018\ub144 \uc124\ub9bd\ub41c \uc2e0\uc57d \ubca4\ucc98\ub85c\uc11c, PROTAC \uae30\ubc18\uc758 \uc2e0\uc57d \ubc0f Novel E3 Ligase \ud50c\ub7ab\ud3fc\uc758 \uc5f0\uad6c\uac1c\ubc1c\uc744 \uc9c4\ud589 \uc911\uc5d0 \uc788\uace0 \uad00\ub828\ud558\uc5ec 50\uac74 \uc774\uc0c1\uc758 \ud2b9\ud5c8\ub97c \ucd9c\uc6d0\ud55c \ubc14 \uc788\ub2e4. \ubd84\ud574 \uae30\uc804\uc758 \uac15\uc810\uc744 \uadf9\ub300\ud654\ud560 \uc218 \uc788\ub294 First-in-class \ub2e8\ubc31\uc9c8 \ud0c0\uac9f\uc744 \uc911\uc2ec\uc73c\ub85c 6\uac1c\uc758 \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc5f0\uad6c\uac1c\ubc1c\ud558\uace0 \uc788\uc73c\uba70 \uadf8 \uc911 \uc18c\uc138\ud3ec\ud3d0\uc554 \uc2e0\uc57d\uc744 \ubaa9\ud45c\ub85c \ud558\ub294 PLK1 PROTAC\uc758 \uacbd\uc6b0, \ud604\uc7ac IND-enabling study\ub97c \uc9c4\ud589\ud568\uacfc \ub3d9\uc2dc\uc5d0 \uae30\uc220\uc774\uc804\uc744 \uc704\ud574 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ud65c\ubc1c\ud788 \ub17c\uc758\ub97c \uc9c4\ud589 \uc911\uc5d0 \uc788\ub2e4. \ub610\ud55c scRNA-seq \ub370\uc774\ud130 \ubd84\uc11d \uae30\ubc18\uc73c\ub85c \uacbd\uc7c1\uc0ac \ub300\ube44 \uc815\ubc00\ud558\uace0 \uc815\ud655\ud558\uac8c \uc720\ub9dd Novel E3 Ligase\ub97c \ubc1c\uad74\ud560 \uc218 \uc788\ub294 \ub3c5\uc790\uc801\uc778 \uae30\uc220 \ud50c\ub7ab\ud3fc\uc778 \uc5c5\uadf8\ub808\uc774\ub354 (UPPGRADER\u2122)\ub97c \uae30\ubc18\uc73c\ub85c \uae30\uc874 CRBN, VHL \ub300\ube44 \ud655\uace0\ud55c \uacbd\uc7c1 \uc6b0\uc704\ub97c \uac16\ub294 4\uac1c Novel E3 Ligase \ud50c\ub7ab\ud3fc\uc5d0 \ub300\ud574 \uc5f0\uad6c\uac1c\ubc1c\uc744 \uc9c4\ud589 \uc911\uc5d0 \uc788\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 \ud0c0\uac9f \uc120\uc815 (Target Identification) \ubd80\ud130 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c\uae4c\uc9c0 \uc57d 2\ub144\uc774 \uc18c\uc694\ub41c PLK1 PROTAC\uc758 \uc2e0\uc18d\ud558\uace0 \uc131\uacf5\uc801\uc778 \uc5f0\uad6c\uac1c\ubc1c \uacbd\ud5d8\uacfc, Live cell assay \ud50c\ub7ab\ud3fc, chemo-proteomics \ub4f1\uc758 \uc6b0\uc218\ud55c PROTAC \uc5f0\uad6c\uac1c\ubc1c \uc778\ud504\ub77c\ub97c \ubc14\ud0d5\uc73c\ub85c \uc720\ud55c\uc591\ud589\uacfc\uc758 \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \ub610\ud55c \uc2e0\uc18d\ud558\uace0 \uc131\uacf5\uc801\uc73c\ub85c \uc218\ud589\ud574 \ub098\uac08 \uc608\uc815\uc774\ub2e4.<\/p>\n<p>\uc720\ud55c\uc591\ud589\uc758 \uc624\uc138\uc6c5 \uc5f0\uad6c\uc18c\uc7a5\uc740 \u201c\ub3c5\uc790\uc801\uc778 PROTAC \uae30\uc220\ub825\uc744 \uac16\ucd98 \uc5c5\ud14c\ub77c\uc640\uc758 \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c\uc744 \uae30\uc058\uac8c \uc0dd\uac01\ud558\uba70, \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ubd84\ud574\ud560 \uc218 \uc788\ub294 \ubb3c\uc9c8\uc744 \uac1c\ubc1c\ud558\uc5ec, \uc54c\uce20\ud558\uc774\uba38\uc640 \uc5fc\uc99d\uc131\uc9c8\ud658 \ud658\uc790\ubd84\ub4e4\uc5d0\uac8c \uc88b\uc740 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4.\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\ub294 \u201c\uc5c5\ud14c\ub77c\uc758 \uc6b0\uc218\ud55c PROTAC \uae30\uc220 \uc5ed\ub7c9\uc774 \uc720\ud55c\uc591\ud589\uc758 \ud48d\ubd80\ud55c \uc2e0\uc57d\uac1c\ubc1c \ubc0f \uc0ac\uc5c5\ud654 \uacbd\ud5d8\uc5d0 \ub354\ud574\uc838 \uae0d\uc815\uc801\uc778 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ucc3d\ucd9c\ud560 \uac83\uc73c\ub85c \uc0dd\uac01\ub418\uace0 \uc720\ud55c\uc591\ud589\uacfc\uc758 \uc720\uae30\uc801\uc774\uace0 \uc804\ud5a5\uc801\uc778 \ud611\uc5c5\uc744 \ud1b5\ud574 \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uac1c\ubc1c\uc5d0 \uc788\uc5b4 \ube60\ub978 \uc2dc\uac04 \ub0b4 \uc720\uc758\ubbf8\ud55c \uc131\uacfc\ub97c \ub3c4\ucd9c\ud558\uaca0\ub2e4\u201d \uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uc5c5\ud14c\ub77c (UPPTHERA)\ub294 \uc720\ud55c\uc591\ud589\uacfc \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uacc4\uc57d\uc744 \ub9fa\uace0, PROTAC Proteolysis Targeting Chimera, \ud45c\uc801\ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\uc220) \uae30\uc220\uc744 \uc774\uc6a9\ud55c \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uac1c\ubc1c\uc744&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35421"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35421"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35421\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}