{"id":35426,"date":"2024-02-26T17:53:55","date_gmt":"2024-02-26T08:53:55","guid":{"rendered":"https:\/\/uppthera.cafe24.com\/?p=35426"},"modified":"2024-02-26T17:53:55","modified_gmt":"2024-02-26T08:53:55","slug":"%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-protac-%ea%b8%b0%eb%b0%98-%ec%8b%a0%ec%95%bd%ea%b0%9c%eb%b0%9c-%ec%a0%84%eb%ac%b8%ea%b8%b0%ec%97%85-%ec%97%85%ed%85%8c%eb%9d%bc-280%ec%96%b5","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2024\/02\/26\/%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-protac-%ea%b8%b0%eb%b0%98-%ec%8b%a0%ec%95%bd%ea%b0%9c%eb%b0%9c-%ec%a0%84%eb%ac%b8%ea%b8%b0%ec%97%85-%ec%97%85%ed%85%8c%eb%9d%bc-280%ec%96%b5\/","title":{"rendered":"[\ubcf4\ub3c4 \uc790\ub8cc] PROTAC \uae30\ubc18 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 \u2018\uc5c5\ud14c\ub77c\u2019, 280\uc5b5\uc6d0 \uc2dc\ub9ac\uc988B \ud22c\uc790 \uc720\uce58 \uc131\uacf5"},"content":{"rendered":"<p><b>\u321c\uc5c5\ud14c\ub77c, 280\uc5b5\uc6d0 Series B \ud22c\uc790 \uc720\uce58 \uc131\uacf5\u2026\uae30\uc874 \ubca4\ucc98\uce90\ud53c\ud0c8 \ubc0f \ud30c\ub77c\ud22c\uc2a4\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, \uba54\ub9ac\uce20\uc99d\uad8c \ucc38\uc5ec<\/b><\/p>\n<p><b>\u321c\uc5c5\ud14c\ub77c, 280\uc5b5\uc6d0 Series B \ud22c\uc790 \uc720\uce58 \uc131\uacf5\u2026\ucd5c\uadfc \uc7ac\ubb34\ub2f4\ub2f9 \uc784\uc6d0 \uc601\uc785\ud558\uba70 \uc0c1\uc7a5 \uc900\ube44\ub97c \uc704\ud55c \uc808\ucc28 \ub3cc\uc785<\/b><\/p>\n<p><b>\uc18c\uc138\ud3ec\ud3d0\uc554 \uc804\uc784\uc0c1\uc5f0\uad6c(IND-enabling study) \ubc0f \ud50c\ub7ab\ud3fc \uae30\uc220 \uc5f0\uad6c\uac1c\ubc1c\ube44 \ub4f1\uc73c\ub85c \uc0ac\uc6a9 \uc608\uc815<\/b><\/p>\n<p>&nbsp;<\/p>\n<p>2022\ub144 05 \uc6d4 18\uc77c(\uc218), PROTAC(Proteolysis Targeting Chimera, \ud45c\uc801\ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\uc220) \uae30\uc220 \uae30\ubc18 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 \u321c\uc5c5\ud14c\ub77c(\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0)\ub294 \uc57d 280\uc5b5\uc6d0 \uaddc\ubaa8\uc758 Series B \ud22c\uc790 \uc720\uce58\ub97c \ub9c8\ubb34\ub9ac\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 \ucd08\uae30 \uc140\ud2b8\ub9ac\uc628\uc774 \uad6d\ub0b4 \uad74\uc9c0\uc758 \ubc14\uc774\uc624\uae30\uc5c5\uc73c\ub85c \uc790\ub9ac\uc7a1\ub294\ub370 \uae30\uc5ec\ud55c \ubc15\uc0ac \ucd9c\uc2e0 5\uba85\uc774 PROTAC \uae30\uc220\uc744 \uc774\uc6a9\ud558\uc5ec \u201c\ub2ff\uc9c0 \uc54a\ub294 \ud658\uc790\uc5d0\uac8c \ud76c\ub9dd\uc744 \uc5f0\uacb0\ud558\uace0 \uac00\ub2a5\uc131\uc744 \ud569\uc131\ud558\uc5ec \uc808\ub9dd\uc744 \ubd84\ud574\ud55c\ub2e4.\u201d \uc2ac\ub85c\uac74\uc73c\ub85c \ub73b\uc744 \ubaa8\uc544 2018\ub144\uc5d0 \uc124\ub9bd\ud558\uc600\ub2e4. \uc124\ub9bd \uc774\ud6c4 PROTAC \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \uc2e0\uc57d\ubb3c\uc9c8\uc744 \ubc1c\uad74\ud558\uc5ec \uc804\uc784\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70, PROTAC \uae30\uc220\uc5d0 \ub300\ud55c \ub3c5\uc790\uc801\uc778 \ud50c\ub7ab\ud3fc \uae30\uc220\uae4c\uc9c0 \ubcf4\uc720\ud558\uace0 \uc788\ub2e4.<\/p>\n<p>\uc124\ub9bd \uc774\ud6c4 \u25b22019\ub144 Pre-Series \uc57d 26\uc5b5\uc6d0 \ud22c\uc790 \uc720\uce58, \u25b22020\ub144 Series A \uc57d 127\uc5b5\uc6d0 \ud22c\uc790 \uc720\uce58 \uc885\ub8cc \uc774\ud6c4 \uc57d 2\ub144\ub9cc\uc5d0 Series B \ud22c\uc790 \uc720\uce58\ub97c \uc644\ub8cc\ud558\uc5ec \ud604\uc7ac\uae4c\uc9c0 \ucd1d 430\uc5b5\uc6d0\uc758 \ud22c\uc790\ub97c \uc720\uce58\ud588\ub2e4.<\/p>\n<p>\uc774\ubc88 \uc2dc\ub9ac\uc988B \uc804\uccb4 \ud22c\uc790 \uc720\uce58 \uae08\uc561\uc740 280\uc5b5\uc6d0\uc774\ub2e4. \uae30\uc874 \uc8fc\uc8fc\uc778 IMM\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, SBI\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, \uc54c\ubc14\ud2b8\ub85c\uc2a4\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, \uc0b0\uc740\uce90\ud53c\ud0c8, \uc778\ub77c\uc774\ud2b8\ubca4\ucc98\uc2a4\uac00 \uc2dc\ub9ac\uc988A \ud22c\uc790\uc5d0 \uc774\uc5b4 \ud6c4\uc18d\ud22c\uc790\ub97c \ud655\uc815\ud558\uc600\uc73c\uba70 \ud30c\ub77c\ud22c\uc2a4\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, \uba54\ub9ac\uce20\uc99d\uad8c\uc73c\ub85c\ubd80\ud130 \uc2e0\uaddc \ud22c\uc790\ub97c \uc720\uce58\ud558\uc600\ub2e4.<\/p>\n<p>PROTAC \uae30\uc220\uc740 \uc138\ud3ec \ub0b4 \ub178\ud654, \uacfc\ubc1c\ud604 \ub2e8\ubc31\uc9c8 \ub4f1 \uc798\ubabb \ub9cc\ub4e4\uc5b4\uc9c4 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294\u00a0<span lang=\"EN-US\">UPP(<\/span>Ubiquitin-Proteasome Pathway)\ub97c \uc778\uc704\uc801\uc73c\ub85c \uadf9\ub300\ud654\uc2dc\ud0a4\ub294 \ucc28\uc138\ub300 \uc2e0\uc57d\uac1c\ubc1c \uae30\uc220\ub85c \u25b2\uc9c8\ubcd1 \uc6d0\uc778 \ub2e8\ubc31\uc9c8 \uacb0\ud569 \ub9ac\uac04\ub4dc, \u25b2\ub9c1\ucee4(linker), \u25b2\ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud45c\uc9c0 \ud6a8\uc18c(E3 ligase) \ub9ac\uac04\ub4dc\uac00 \ud558\ub098\uc758 \ubd84\uc790\ub97c \uc774\ub8e8\ub294 \u2018\uc774\uc911\uae30\ub2a5 \uc800\ubd84\uc790 \ud654\ud569\ubb3c\u2019\uc774\ub2e4.<\/p>\n<p>PROTAC \uad00\ub828 \uc5f0\uad6c\uac1c\ubc1c\uc740 \ubbf8\uad6d \uc2e0\uc57d\uac1c\ubc1c \ubca4\ucc98\uae30\uc5c5\ub4e4\uc774 \uc120\ub3c4\ud558\uace0 \uc788\uc73c\uba70, \ubbf8\uad6d Nasdaq \uc2dc\uc7a5\uc5d0\ub294 Arvinas, Kymera therapeutics, Nurix therapeutics, C4 therapeutics\uac00 0.5~2.5\uc870\uc6d0 \uaddc\ubaa8\ub85c \uc0c1\uc7a5\ub418\uc5b4 \uc788\ub2e4. \ucd5c\uadfc \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\uc778 \ud654\uc774\uc790, \ub85c\uc288, \uc0ac\ub178\ud53c \ub4f1\uc740 \ucd08\uae30 \uac1c\ubc1c \uc9c4\ub3c4\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 PROTAC \uc2e0\uc57d\uac1c\ubc1c \ubca4\ucc98\uae30\uc5c5\ub4e4\uacfc \uc218\uc870\uc6d0\ub300 \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uad00\ub828 \ub2e4\uc218\uc758 \uacc4\uc57d\uc744 \uccb4\uacb0\ud558\uace0 \uc788\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 \ucd5c\uadfc \uc720\ud55c\uc591\ud589\uacfc \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \uc2e0\uc57d\uc5d0 \ub300\ud55c \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uacc4\uc57d\uc744 \uccb4\uacb0\ud55c \ubc14 \uc788\ub2e4. \ud574\ub2f9 \ud30c\uc774\ud504\ub77c\uc778 \uc678\uc5d0\ub3c4 \ud604\uc7ac 6\uac1c\uc758 PROTAC \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc5f0\uad6c \uac1c\ubc1c \uc911\uc5d0 \uc788\ub2e4.<\/p>\n<p>\uadf8 \uc911 \uc18c\uc138\ud3ec\ud3d0\uc554\uc744 \uc801\uc751\uc99d\uc73c\ub85c \ud558\ub294 \ud601\uc2e0\uc2e0\uc57d(First-in-class)\uc774 \uac00\uc7a5 \ube60\ub974\uac8c \uc784\uc0c1\uc5d0 \uc9c4\uc785\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub41c\ub2e4. \uc5c5\ud14c\ub77c\ub294 PROTAC \uae30\uc220\uc744 \uc774\uc6a9\ud558\uc5ec \uc138\ud3ec\uc8fc\uae30(Cell cycle)\uac00 \ud65c\ubc1c\ud788 \uc9c4\ud589\ub418\ub294 \uc18c\uc138\ud3ec\ud3d0\uc554\uc5d0 \uc788\uc5b4 \uadfc\ubcf8\uc801\uc73c\ub85c \uacfc\ubc1c\ud604\ub418\ub294 PLK1 \ub2e8\ubc31\uc9c8\uc758 \uc9c1\uc811\ubd84\ud574\ub97c \ud1b5\ud574 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\uc8fc\uae30(Cell cycle)\ub97c \uba48\ucd94\uace0 \uc554\uc138\ud3ec \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\ub294 \uc2e0\uc57d\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4.<\/p>\n<p>\ud604\uc7ac \uc18c\uc138\ud3ec\ud3d0\uc554 \ud601\uc2e0\uc2e0\uc57d\uc740 \uae00\ub85c\ubc8c \uc784\uc0c1\uc218\ud0c1(CRO) \uc5c5\uccb4\uc640 \uc804\uc784\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70, \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc CDA\ub97c \uccb4\uacb0\ud558\uba70 \uae00\ub85c\ubc8c \uae30\uc220\uc774\uc804\uc744 \uc704\ud55c \ub17c\uc758\ub3c4 \uc774\uc5b4 \ub098\uac00\uace0 \uc788\ub2e4. 2023\ub144 \ubbf8\uad6d\uc5d0\uc11c \uc784\uc0c11\uc0c1\uc744 \uc9c4\ud589\ud560 \uacc4\ud68d\uc774\ub2e4. \uae08\ubc88 Series B \ud22c\uc790 \uc720\uce58\uae08\uc740 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud601\uc2e0\uc2e0\uc57d\uc758 \uae00\ub85c\ubc8c \uc0ac\uc5c5\ud654\ub97c \uc704\ud55c \uc804\uc784\uc0c1\uc5f0\uad6c \ube44\uc6a9 \ub4f1\uc73c\ub85c \uc0ac\uc6a9\ub420 \uc608\uc815\uc774\ub2e4.<\/p>\n<p>\ub610\ud55c, \uc5c5\ud14c\ub77c\ub294 \ud601\uc2e0\uc2e0\uc57d \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud50c\ub7ab\ud3fc \uae30\uc220 \ubcf4\uc720 \uc81c\uc57d\uc0ac\ub85c\uc11c\uc758 \uc5ed\ub7c9\uc744 \uac15\ud654\ud558\uae30 \uc704\ud55c \uc5f0\uad6c\uac1c\ubc1c\uc5d0\ub3c4 \ud22c\uc790\ub97c \uac15\ud654\ud574 \ub098\uac00\uace0 \uc788\ub2e4. \uc0dd\uba85\uc815\ubcf4\ud559(Bioinformatics) \uc5ed\ub7c9\uc744 \ubc14\ud0d5\uc73c\ub85c \ub2e8\uc77c\uc138\ud3ec \uc218\uc900\uc5d0\uc11c AI\ub97c \ud65c\uc6a9\ud574 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud55c \ub4a4 \uc0c8\ub85c\uc6b4(Novel) E3 Ligase\ub97c \ubc1c\uad74\ud574 \ub0b4\ub294 \uc5c5\uadf8\ub808\uc774\ub354(UPPGRADER\u2122) \ud504\ub85c\uadf8\ub7a8\uc744 \ud1b5\ud574 4\uac1c\uc758 Novel E3 ligase \ud50c\ub7ab\ud3fc \uae30\uc220\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac1c\ubc1c\uc744 \uc9c4\ud589 \uc911\uc5d0 \uc788\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 \ud30c\uc774\ud504\ub77c\uc778\uc758 \uc784\uc0c1 \uc9c4\uc785 \ubc0f \ud6c4\uc18d \ud30c\uc774\ud504\ub77c\uc778\uacfc \ud50c\ub7ab\ud3fc \uae30\uc220\uc758 \uc5f0\uad6c\uc131\uacfc\ub97c \uae30\ubc18\uc73c\ub85c \ucf54\uc2a4\ub2e5 \uc2dc\uc7a5\uc5d0 \uc0c1\uc7a5\uc744 \uacc4\ud68d\ud558\uace0 \uc788\ub2e4. \uc774\uc5d0 \uc9c0\ub09c 4\uc6d4 CRISPR \ud50c\ub7ab\ud3fc \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c 2021\ub144 12\uc6d4 \uc0c1\uc7a5\ud55c \u321c\ud234\uc820\uc758 \ucf54\uc2a4\ub2e5 \uc0c1\uc7a5 \uc2e4\ubb34\ub97c \ucd1d\uad04\ud55c \uc2ec\ud604\uc2b9 \u524d \ud234\uc820 \uae30\ud68d\/\ud64d\ubcf4\uc2e4\uc7a5\uc744 \uc7ac\ubb34\ub2f4\ub2f9 \uc784\uc6d0\uc73c\ub85c \uc601\uc785\ud558\uc600\ub2e4. \uc62c\ud574\ubd80\ud130 \ub0b4\ubd80 \uc2dc\uc2a4\ud15c \uc815\ube44, \uc8fc\uad00\uc0ac \uc120\uc815, \uc9c0\uc815\uac10\uc0ac \uc120\uc784 \ub4f1 \uc0c1\uc7a5 \uc900\ube44\ub97c \uc704\ud55c \uc808\ucc28\uc5d0 \ub3cc\uc785\ud560 \uc608\uc815\uc774\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\uc774\uc0ac\ub294 \u201c\uc5c5\ud14c\ub77c\ub9cc\uc758 PROTAC \uae30\ubc18 \ud601\uc2e0\uc2e0\uc57d \uae30\uc220 \ubc0f \ud50c\ub7ab\ud3fc \uae30\uc220\uc758 \uac00\uce58\ub97c \uc778\uc815\ubc1b\uc544 \uc5b4\ub824\uc6b4 \ubc14\uc774\uc624 \ud22c\uc2ec \ud658\uacbd\uc5d0\uc11c\ub3c4 \uc131\uacf5\uc801\uc73c\ub85c \ud22c\uc790\ub97c \uc720\uce58\ud560 \uc218 \uc788\uc5c8\ub2e4.\u201d\uba70, \u201c\ud22c\uc790\uae08\uc73c\ub85c PROTAC \ud50c\ub7ab\ud3fc \uae30\uc220\uc758 \uacbd\uc7c1\ub825\uc744 \uadf9\ub300\ud654\ud558\uace0 \uc18c\uc138\ud3ec\ud3d0\uc554 \uc2e0\uc57d\uc758 \uae00\ub85c\ubc8c \uc0ac\uc5c5\ud654\ub97c \ubcf8\uaca9\ud654\ud560 \uac83\u201d\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u321c\uc5c5\ud14c\ub77c, 280\uc5b5\uc6d0 Series B \ud22c\uc790 \uc720\uce58 \uc131\uacf5\u2026\uae30\uc874 \ubca4\ucc98\uce90\ud53c\ud0c8 \ubc0f \ud30c\ub77c\ud22c\uc2a4\uc778\ubca0\uc2a4\ud2b8\uba3c\ud2b8, \uba54\ub9ac\uce20\uc99d\uad8c \ucc38\uc5ec \u321c\uc5c5\ud14c\ub77c, 280\uc5b5\uc6d0 Series B \ud22c\uc790 \uc720\uce58 \uc131\uacf5\u2026\ucd5c\uadfc \uc7ac\ubb34\ub2f4\ub2f9&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35426"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35426"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35426\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}