{"id":35431,"date":"2024-02-26T17:56:52","date_gmt":"2024-02-26T08:56:52","guid":{"rendered":"https:\/\/uppthera.cafe24.com\/?p=35431"},"modified":"2024-02-26T17:56:52","modified_gmt":"2024-02-26T08:56:52","slug":"%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-%eb%b0%94%ec%9d%b4%ec%98%a4-usa-%ec%b0%b8%ea%b0%80-plk1-%eb%b6%84%ed%95%b4%ec%95%bd%eb%ac%bc%ec%9d%98-%ea%b8%b0%ec%88%a0","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2024\/02\/26\/%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-%eb%b0%94%ec%9d%b4%ec%98%a4-usa-%ec%b0%b8%ea%b0%80-plk1-%eb%b6%84%ed%95%b4%ec%95%bd%eb%ac%bc%ec%9d%98-%ea%b8%b0%ec%88%a0\/","title":{"rendered":"[\ubcf4\ub3c4 \uc790\ub8cc] \uc5c5\ud14c\ub77c, \ubc14\uc774\uc624 USA \ucc38\uac00.. \u201cPLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758\u201d"},"content":{"rendered":"<p><b>\u321c\uc5c5\ud14c\ub77c, \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ube44\uc784\uc0c1\uc744 \uc9c4\ud589 \uc911\uc778 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud56d\uc554\uc2e0\uc57d\uc778 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758 \uc608\uc815<\/b><\/p>\n<p><b>\u321c\uc5c5\ud14c\ub77c, PLK1\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554 \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8 2023\ub144 \uc784\uc0c1 1\uc0c1 \uc9c4\uc785 \uc608\uc815<\/b><\/p>\n<p>&nbsp;<\/p>\n<p class=\"0\"><span lang=\"EN-US\">PROTAC\u00a0<\/span>\uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5\uc778\u00a0<span lang=\"EN-US\">(<\/span>\uc8fc<span lang=\"EN-US\">)<\/span>\uc5c5\ud14c\ub77c\u00a0<span lang=\"EN-US\">(<\/span>\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0<span lang=\"EN-US\">)<\/span>\uac00 \uc138\uacc4 \ucd5c\ub300 \ubc14\uc774\uc624 \ud589\uc0ac\uc778 \ubc14\uc774\uc624\u00a0<span lang=\"EN-US\">USA<\/span>\uc5d0 \ucc38\uac00\ud55c\ub2e4\uace0\u00a0<span lang=\"EN-US\">13<\/span>\uc77c \ubc1d\ud614\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\uc62c\ud574 \ubc14\uc774\uc624\u00a0<span lang=\"EN-US\">USA<\/span>\ub294\u00a0<span lang=\"EN-US\">6<\/span>\uc6d4\u00a0<span lang=\"EN-US\">13<\/span>\uc77c\ubd80\ud130\u00a0<span lang=\"EN-US\">16<\/span>\uc77c<span lang=\"EN-US\">(<\/span>\ud604\uc9c0\uc2dc\uac04<span lang=\"EN-US\">)<\/span>\uae4c\uc9c0 \ub098\ud758\uac04 \ubbf8\uad6d \uc0cc\ub514\uc5d0\uace0\uc5d0\uc11c \uc624\ud504\ub77c\uc778 \ud589\uc0ac\ub85c \uac1c\ucd5c\ub41c\ub2e4<span lang=\"EN-US\">. \u00a0<\/span><\/p>\n<p class=\"0\">\uc5c5\ud14c\ub77c\ub294 \uc0ac\uc804\uc5d0 \uc870\uc728\ub41c\u00a0<span lang=\"EN-US\">20<\/span>\uc5ec\uac74\uc758 \uc7a0\uc7ac \ub77c\uc774\uc120\uc2dc \ubbf8\ud305\uc744 \ud1b5\ud574 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \uae30\uc220<span lang=\"EN-US\">(PROTAC)\u00a0<\/span>\uae30\ubc18\uc758 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud56d\uc554\uc2e0\uc57d\uc778\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758\ub97c \uc9c4\ud589\ud560 \uc608\uc815\uc774\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\uc5c5\ud14c\ub77c\ub294\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc758 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc774 \ub3c4\ucd9c\ub41c \uc62c\ud574\u00a0<span lang=\"EN-US\">1<\/span>\uc6d4\ubd80\ud130 \ud574\ub2f9 \uc2e0\uc57d\ud6c4\ubcf4\ubb3c\uc9c8\uc758 \uae30\uc220\uc218\ucd9c\uc744 \uc704\ud55c \uc0ac\uc5c5\uac1c\ubc1c \ud65c\ub3d9\uc744 \uc2dc\uc791\ud558\uc600\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\uc9c0\ub09c\u00a0<span lang=\"EN-US\">1<\/span>\uc6d4 \uc81c\uc774\ud53c\ubaa8\uac74 \ud5ec\uc2a4\ucf00\uc5b4 \ucee8\ud37c\ub7f0\uc2a4\uc5d0\uc11c \ub2e4\uc218\uc758 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \uccab \ubbf8\ud305\uc744 \uc9c4\ud589\ud55c \uc774\ud6c4\u00a0<span lang=\"EN-US\">4<\/span>\uc6d4 \ubbf8\uad6d\uc554\uc5f0\uad6c\ud559\ud68c<span lang=\"EN-US\">(AACR),\u00a0<\/span>\uadf8\ub9ac\uace0 \ud604\uc7ac \ubc14\uc774\uc624\u00a0<span lang=\"EN-US\">USA<\/span>\uae4c\uc9c0 \uc8fc\uc694 \ud589\uc0ac\ub4e4\uc744 \ud1b5\ud574 \ud574\ub2f9 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ube44\ubc00\uc720\uc9c0\uacc4\uc57d<span lang=\"EN-US\">(CDA)<\/span>\uc5d0 \uae30\ubc18\ud55c \ub370\uc774\ud130 \ubbf8\ud305\uc744 \uc774\uc5b4\uc624\uba70\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c\uc744 \uc704\ud55c \uc2e0\ub8b0\uad00\uacc4\ub97c \uad6c\ucd95\ud558\uace0 \uc788\ub2e4<span lang=\"EN-US\">. \u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n<p class=\"0\"><span lang=\"EN-US\">PLK1<\/span>\uc740 \uc138\ud3ec\uc8fc\uae30\u00a0<span lang=\"EN-US\">G2, M<\/span>\uae30\uc758 \uc138\ud3ec \ubd84\uc5f4\ud65c\ub3d9\uc744 \uad11\ubc94\uc704\ud558\uac8c \uad00\uc7a5\ud558\uace0 \uc788\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\ub610\ud55c<span lang=\"EN-US\">,\u00a0<\/span>\uc138\ud3ec\ubd84\uc5f4\uc5d0 \uc788\uc5b4 \ud544\uc218\uc801\uc778 \uce74\uc774\ub124\uc774\uc988<span lang=\"EN-US\">(Kinase)\u00a0<\/span>\ub2e8\ubc31\uc9c8\ub85c\uc11c \uc554\uc138\ud3ec\uc640 \uac19\uc774 \ud65c\ubc1c\ud558\uac8c \ubd84\uc5f4\ud558\ub294 \uc138\ud3ec\uc5d0 \uacfc\ubc1c\ud604 \ub41c\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\ub9ce\uc740 \uc120\ud589\uc5f0\uad6c\ub4e4\uc744 \ud1b5\ud574\uc11c\u00a0<span lang=\"EN-US\">PLK1<\/span>\uc774 \ub2e4\uc591\ud55c \uc554\uc885\uc5d0 \uace0\ub974\uac8c \uacfc\ubc1c\ud604 \ud558\uace0<span lang=\"EN-US\">, PLK1<\/span>\uc758 \ubc1c\ud604\ub7c9\uc774 \uc554\ud658\uc790\uc758 \uc784\uc0c1 \uc608\ud6c4\uc640 \ub192\uc740 \uad00\ub828\uc131\uc774 \uc788\ub2e4\ub294 \uac83\uc774 \ubc1d\ud600\uc9c0\uba74\uc11c\u00a0<span lang=\"EN-US\">PLK1<\/span>\uc740 \uc720\ub9dd\ud55c \ud56d\uc554 \uc57d\ubb3c \ud0c0\uac9f\uc73c\ub85c \uc5ec\uaca8\uc9c0\uace0 \uc788\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\uc774\uc5d0 \ubca0\ub9c1\uac70\uc789\uac94\ud558\uc784<span lang=\"EN-US\">,\u00a0<\/span>\ub2e4\ucf00\ub2e4<span lang=\"EN-US\">,\u00a0<\/span>\uae00\ub77d\uc18c\ubbf8\uc2a4\ud074\ub77c\uc778\uc744 \ud3ec\ud568\ud55c \ub9ce\uc740 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uc774\u00a0<span lang=\"EN-US\">PLK1<\/span>\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\uc8fc\uae30\ub97c\u00a0<span lang=\"EN-US\">G2\/M<\/span>\uae30\uc5d0 \uc815\uc9c0\uc2dc\ud0a4\uace0 \uc554\uc138\ud3ec \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\ub294 \uc57d\ubb3c\uae30\uc804\uc5d0 \uae30\ubc18\ud55c\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c\u00a0<span lang=\"EN-US\">(Small molecule inhibitor)\u00a0<\/span>\uac1c\ubc1c\uc744 \uc2dc\ub3c4\ud558\uc600\uc73c\ub098<span lang=\"EN-US\">,\u00a0<\/span>\ub300\ubd80\ubd84 \uc784\uc0c1\uc2dc\ud5d8 \ub2e8\uacc4\uc5d0\uc11c \uc6a9\ub7c9\uc81c\ud55c\ub3c5\uc131\ubc18\uc751\u00a0<span lang=\"EN-US\">(Dose-limiting toxicity)<\/span>\uc73c\ub85c \uc778\ud574 \uc2e4\ud328\ud55c \ubc14 \uc788\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\ud604\uc7ac\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c \ub610\ub294 \ubd84\ud574\ud558\ub294 \uae30\uc804\uc73c\ub85c \ud5c8\uac00 \uc2b9\uc778\ub41c \uc57d\ubb3c\uc740 \uc5c6\ub294 \uc0c1\ud669\uc774\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\"><span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c\ub4e4\uc758 \uc8fc\uc694\ud55c \uc2e4\ud328\uc0ac\uc720\ub294<span lang=\"EN-US\">,\u00a0<\/span>\u25b2\uc810\uc720 \uae30\ubc18 \uc791\uc6a9\uae30\uc804\u00a0<span lang=\"EN-US\">(Occupancy-driven MoA)\u00a0<\/span>\uc0c1 \uc554\uc138\ud3ec\uac00\u00a0<span lang=\"EN-US\">G\/2M<\/span>\uc5d0 \uba48\ucdc4\uc744 \ub54c \ucd95\uc801\ub418\ub294\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc5b5\uc81c\ud560 \uc218 \uc5c6\uc5b4 \ucda9\ubd84\ud55c \ud56d\uc554 \ud6a8\ub2a5\uc744 \ub3c4\ucd9c\ud560 \uc218 \uc5c6\uc5c8\uace0\u00a0\u25b2\uce74\uc774\ub124\uc774\uc988 \uc800\ud574\uc81c \ud2b9\uc131 \uc0c1 \ub0ae\uc740 \uc120\ud0dd\uc131\uc73c\ub85c \uc778\ud55c\u00a0<span lang=\"EN-US\">Off-target\u00a0<\/span>\ubb38\uc81c\ub85c \uc57d\ubb3c\ub3c5\uc131\uc774 \ub098\ud0c0\ub0ac\ub358 \uac83 \ub54c\ubb38\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\uc5c5\ud14c\ub77c\ub294 \uae30\uc874\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c\ub4e4\uc758 \uc2e4\ud328 \uc6d0\uc778\uc744 \uadf9\ubcf5\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \ud310\ub2e8\ud558\uace0\u00a0<span lang=\"EN-US\">PROTAC\u00a0<\/span>\uae30\uc220 \uae30\ubc18\uc758\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c \uac1c\ubc1c\uc744 \uae30\ud68d\ud558\uc600\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\uc5c5\ud14c\ub77c\uc758\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc740 \uc9c0\uc18d\uc801\uc73c\ub85c \ud0c0\uac9f \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294\u00a0<span lang=\"EN-US\">PROTAC<\/span>\uc758 \uc774\ubca4\ud2b8 \uae30\ubc18 \uc791\uc6a9\uae30\uc804\u00a0<span lang=\"EN-US\">(Event-driven MoA)\u00a0<\/span>\ud2b9\uc131\uc744 \ud1b5\ud574\u00a0<span lang=\"EN-US\">G\/2M\u00a0<\/span>\uae30 \uc815\uc9c0 \uc2dc\uc5d0 \ucd95\uc801\ub418\ub294\u00a0<span lang=\"EN-US\">PLK1<\/span>\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uacf5\ub7b5\ud55c\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\ub610\ud55c<span lang=\"EN-US\">,\u00a0<\/span>\uc0bc\uc911 \ubcf5\ud569\uccb4 \ud615\uc131<span lang=\"EN-US\">(Ternary complex formation)<\/span>\uc744 \ud1b5\ud55c \ud0c0\uac9f \uc120\ud0dd\uc131\uc744 \ub192\uc77c \uc218 \uc788\ub294\u00a0<span lang=\"EN-US\">PROTAC<\/span>\uc758 \ud2b9\uc131\uc744 \ud1b5\ud574\u00a0<span lang=\"EN-US\">Off-target\u00a0<\/span>\uad00\ub828 \ub3c5\uc131\uc744 \uae30\uc874\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c \ub300\ube44 \ud604\uc800\ud558\uac8c \uc904\uc600\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\ud604\uc7ac \uc5c5\ud14c\ub77c\ub294 \uc18c\uc138\ud3ec\ud3d0\uc554\uc744 \uc8fc\uc694 \uc801\uc751\uc99d\uc73c\ub85c \ud558\ub294\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c \uac1c\ubc1c\uc744 \uc2dc\uc791\ud55c\uc9c0\u00a0<span lang=\"EN-US\">2<\/span>\ub144\uc5ec\ub9cc\uc5d0 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \ub3c4\ucd9c\ud558\uc600\uace0<span lang=\"EN-US\">,\u00a0<\/span>\uae30\uc874\uc758\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c \uc2e4\ud328 \uc0ac\uc720\ub97c\u00a0<span lang=\"EN-US\">PROTAC\u00a0<\/span>\ubaa8\ub2ec\ub9ac\ud2f0\ub97c \ud1b5\ud574 \uc815\ud655\ud788 \uadf9\ubcf5\ud55c \uc2e4\ud5d8 \ub370\uc774\ud130\ub97c \ub3d9\ubb3c \uc218\uc900\uae4c\uc9c0 \ucda9\ubd84\ud788 \ud655\ubcf4\ud558\uc600\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\uc774\ub97c \ubc14\ud0d5\uc73c\ub85c\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c\uc744 \uc704\ud55c \uc0ac\uc5c5\uac1c\ubc1c \ud65c\ub3d9\uc744 \uc9c4\ud589 \uc911\uc5d0 \uc788\uc73c\uba70 \ud2b9\ud788 \uc2ec\ub3c4 \uc788\ub294 \uc791\uc6a9 \uae30\uc804 \uc5f0\uad6c \ub370\uc774\ud130\ub97c \ud1b5\ud574 \uc6b0\uc218\ud55c \ud56d\uc554 \ud6a8\ub2a5 \uacb0\uacfc\ub97c \ub17c\ub9ac\uc801\uc73c\ub85c \ub4b7\ubc1b\uce68\ud568\uc73c\ub85c\uc368 \uc7a0\uc7ac \ub77c\uc774\uc120\uc2dc\ub4e4\uc5d0\uac8c \ubcf4\ub2e4 \uc124\ub4dd\ub825 \uc788\uac8c \uc57d\ubb3c\uc758 \uac00\uce58\uc640 \uac00\ub2a5\uc131\uc744 \uc804\ub2ec\ud558\uace0 \uc788\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\ud604\uc7ac\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc740\u00a0<span lang=\"EN-US\">CMC\u00a0<\/span>\ubc0f\u00a0<span lang=\"EN-US\">IND-Enabling study<\/span>\ub97c \uc9c4\ud589 \uc911\uc5d0 \uc788\uc73c\uba70\u00a0<span lang=\"EN-US\">2023<\/span>\ub144 \uc784\uc0c1\u00a0<span lang=\"EN-US\">1<\/span>\uc0c1\uc744 \uc9c4\ud589\ud560 \uacc4\ud68d\uc774\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\uc5c5\ud14c\ub77c\ub294\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc774\u00a0\u25b2<span lang=\"EN-US\">PLK1<\/span>\uc744 \uc5b5\uc81c<span lang=\"EN-US\">(<\/span>\ubd84\ud574<span lang=\"EN-US\">)<\/span>\ud558\ub294 \ucd5c\ucd08\uc758\u00a0<span lang=\"EN-US\">(First-in class)\u00a0<\/span>\ud56d\uc554 \uc2e0\uc57d\uc774\uc790\u00a0\u25b2<span lang=\"EN-US\">PROTAC\u00a0<\/span>\uc5c5\uacc4\uc5d0\uc11c \uac1c\ubc1c \ub09c\uc774\ub3c4\uac00 \ub192\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub294 \uc138\ud3ec \uc8fc\uae30\u00a0<span lang=\"EN-US\">(Cell cycle)\u00a0<\/span>\uad00\ub828 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \ucd5c\ucd08\uc758 \uc784\uc0c1 \ud30c\uc774\ud504\ub77c\uc778\uc774 \ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ud558\uace0 \uc788\ub2e4<span lang=\"EN-US\">.\u00a0<\/span>\ub354\ubd88\uc5b4 \ud604\uc7ac \uc5c5\ud14c\ub77c\ub294\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uacfc \uad00\ub828\ud558\uc5ec\u00a0<span lang=\"EN-US\">25<\/span>\uac74\uc758 \uad6d\ub0b4 \ubc0f\u00a0<span lang=\"EN-US\">PCT\u00a0<\/span>\ubb3c\uc9c8\ud2b9\ud5c8\ub97c \ucd9c\uc6d0\ud558\uc600\uace0 \uacc4\uc18d\ud574\uc11c \ud2b9\ud5c8 \uc7a5\ubcbd\uc744 \uad6c\ucd95\ud574 \ub098\uac00\uba74\uc11c<span lang=\"EN-US\">, PLK1\u00a0<\/span>\ubd84\ud574 \uc601\uc5ed\uc5d0 \uc788\uc5b4\uc11c\ub294 \ud6c4\ubc1c\uc8fc\uc790 \uc9c4\uc785\uc744 \uc6d0\ucc9c \ucc28\ub2e8\ud558\uace0\u00a0<span lang=\"EN-US\">First-in-class<\/span>\uc758 \uc785\uc9c0\ub97c \ud655\uace0\ud788 \ud558\uace0\uc790 \ub178\ub825\ud558\uace0 \uc788\ub2e4<span lang=\"EN-US\">.<\/span><\/p>\n<p class=\"0\">\uc5c5\ud14c\ub77c\uc758 \uc190\uc0b0\ud558 \ucd5c\uace0 \uc0ac\uc5c5\uac1c\ubc1c \ucc45\uc784\uc790<span lang=\"EN-US\">(CBO)<\/span>\ub294\u00a0<span lang=\"EN-US\">\u201c<\/span>\ub2f9\uc0ac\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\ubd84\ud574\uc57d\ubb3c\uc740<span lang=\"EN-US\">,\u00a0<\/span>\uae30\uc874\u00a0<span lang=\"EN-US\">PLK1\u00a0<\/span>\uc800\ubd84\uc790 \uc800\ud574\uc81c\uc758 \uc2e4\ud328\uc0ac\ub840\ub97c\u00a0<span lang=\"EN-US\">PROTAC\u00a0<\/span>\ubaa8\ub2ec\ub9ac\ud2f0\ub85c \uadf9\ubcf5\ud560 \uc218 \uc788\ub2e4\ub294 \uba85\ud655\ud55c \ud30c\uc774\ud504\ub77c\uc778 \uc2a4\ud1a0\ub9ac\uc640 \uc774\ub97c \ucda9\ubd84\ud788 \ub4b7\ubc1b\uce68\ud558\ub294 \ub17c\ub9ac\uc801\uc778 \uc2e4\ud5d8 \ub370\uc774\ud130\ub97c \ud655\ubcf4\ud588\ub2e4<span lang=\"EN-US\">.\u201d<\/span>\uba70<span lang=\"EN-US\">, \u201c<\/span>\uc62c\ud574\ucd08\ubd80\ud130 \uc774\uc5b4\uc9c4 \uc0ac\uc5c5\uac1c\ubc1c \ubbf8\ud305\ub4e4\uc5d0\uc11c \ub2e4\uc218\uc758 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uc774 \uad6c\uccb4\uc801\uc778 \uad00\uc2ec\uacfc \uc2e0\ub8b0\ub97c \ubcf4\uc5ec\uc8fc\uace0 \uc788\ub294 \ub9cc\ud07c<span lang=\"EN-US\">,\u00a0<\/span>\uae08\ubc88 \ubc14\uc774\uc624\u00a0<span lang=\"EN-US\">USA<\/span>\uc5d0\uc11c \uae30\uc220\uc218\ucd9c\uacfc \uad00\ub828\ub41c \uad6c\uccb4\uc801\uc778 \ub17c\uc758\ub97c \uc9c4\ud589\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc0dd\uac01\ud55c\ub2e4<span lang=\"EN-US\">.\u201d<\/span>\uace0 \ubc1d\ud614\ub2e4<span lang=\"EN-US\">.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u321c\uc5c5\ud14c\ub77c, \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ube44\uc784\uc0c1\uc744 \uc9c4\ud589 \uc911\uc778 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud56d\uc554\uc2e0\uc57d\uc778 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758 \uc608\uc815 \u321c\uc5c5\ud14c\ub77c, PLK1\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35431"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35431"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35431\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}