\uc5c5\ud14c\ub77c, \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ube44\uc784\uc0c1\uc744 \uc9c4\ud589 \uc911\uc778 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud56d\uc554\uc2e0\uc57d\uc778 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758 \uc608\uc815<\/b><\/p>\n
\uc5c5\ud14c\ub77c, PLK1\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554 \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8 2023\ub144 \uc784\uc0c1 1\uc0c1 \uc9c4\uc785 \uc608\uc815<\/b><\/p>\n
<\/p>\n
PROTAC \uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 (\uc8fc)\uc5c5\ud14c\ub77c (\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0)\ub294 \uc18c\uc138\ud3ec\ud3d0\uc554\uc744 \uc8fc\uc694 \uc801\uc751\uc99d\uc73c\ub85c \ud558\ub294 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc774 \uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\ub2e8(KDDF, \ub2e8\uc7a5 \ubb35\ud604\uc0c1)\uc758 \uc2e0\uaddc \ube44\uc784\uc0c1 \uc9c0\uc6d0 \uacfc\uc81c\ub85c \uc120\uc815\ub410\ub2e4\uace0 21\uc77c \ubc1d\ud614\ub2e4.<\/p>\n
\uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\uc740 \uad6d\ub0b4 \uc81c\uc57d, \ubc14\uc774\uc624\uc0b0\uc5c5\uc758 \uae00\ub85c\ubc8c \uacbd\uc7c1\ub825 \uac15\ud654\uc640 \uad6d\ubbfc\uac74\uac15 \uc99d\uc9c4\uc744 \uc704\ud574 \uc720\ud6a8, \uc120\ub3c4, \ud6c4\ubcf4, \ube44\uc784\uc0c1, \uc784\uc0c1\ub2e8\uacc4 \ub4f1 \uc2e0\uc57d\uac1c\ubc1c \uc804\uc8fc\uae30\ub97c \uc9c0\uc6d0\ud558\ub294 \ubc94\ubd80\ucc98 \uc815\ubd80\uc9c0\uc6d0\uc0ac\uc5c5\uc774\ub2e4. \uad6d\ub0b4 \uc2e0\uc57d\uac1c\ubc1c R&D \uc0dd\ud0dc\uacc4\ub97c \uac15\ud654\ud558\uace0 \uae00\ub85c\ubc8c \uae30\uc220\uc774\uc804\uacfc \ubbf8\uad6d FDA \uc2e0\uc57d \uc2b9\uc778 \ub4f1 \uc131\uacfc\ub97c \ucc3d\ucd9c\ud558\uae30 \uc704\ud574 \ud601\uc2e0 \uc2e0\uc57d\uc758 \uac1c\ubc1c \ub2e8\uacc4\ubcc4 \uc720\ub9dd \ubb3c\uc9c8\uc744 \uc120\uc815\ud558\uc5ec \uc5f0\uad6c\ube44\ub97c \uc9c0\uc6d0\ud55c\ub2e4.<\/p>\n
\uc5c5\ud14c\ub77c\uac00 \uc120\uc815\ub41c \uad6d\uac00\uc2e0\uc57d R&D \uc0dd\ud0dc\uacc4 \uad6c\ucd95 \uc5f0\uad6c\ub294 \ud6c4\ubcf4, \ube44\uc784\uc0c1 \ub2e8\uacc4\uc758 \uacfc\uc81c\ub97c \ub300\uc0c1\uc73c\ub85c\ud6c4\ubcf4\ubb3c\uc9c8\uc758 \ube44\uc784\uc0c1 \uc5f0\uad6c \ubc0f IND \uc2b9\uc778\uc744 \uc704\ud55c \uc5f0\uad6c\ube44\ub97c \uc9c0\uc6d0\ud558\ub294 \uc0ac\uc5c5\uc774\ub2e4. \ud604\uc7ac \uc5c5\ud14c\ub77c\ub294 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8\uc5d0 \ub300\ud574 CMC \ubc0f IND-Enabling study\ub97c \uc9c4\ud589 \uc911\uc5d0 \uc788\uc73c\uba70, 2023\ub144\ub9d0 \uc784\uc0c1 1\uc0c1\uc5d0 \uc9c4\uc785\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ud558\uace0 \uc788\ub2e4.<\/p>\n
\uc18c\uc138\ud3ec\ud3d0\uc554(SCLC)\uc740 \uc9c0\ub09c 30\ub144\uac04 \uc2e0\uc57d\uac1c\ubc1c\uc758 \ubd88\ubaa8\uc9c0\ub85c \ubd88\ub9ac\ub358 \ub09c\uce58\uc554\uc73c\ub85c\uc11c, \uc804\uccb4 \ud3d0\uc554\uc758 10~15%\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\ub2e4. \ub610\ud55c, \uc885\uc591\uc758 \uc804\uc774 \uc18d\ub3c4\uac00 \ube60\ub974\uace0 \uc7ac\ubc1c\ub960\uc774 \ub192\uc544 5\ub144 \uc0dd\uc874\uc728\uc774 7% \ubbf8\ub9cc \uc218\uc900\uc73c\ub85c \ub9e4\uc6b0 \ub0ae\uc740 \ub09c\uce58\uc554\uc774\ub2e4. \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\uc758 \uacbd\uc6b0 \uc2e0\ub8b0\ub3c4 \ub192\uc740 Biomarker\ub97c \uae30\ubc18\uc73c\ub85c \ub2e4\uc218\uc758 \ud45c\uc801 \ud56d\uc554\uc81c \uac1c\ubc1c\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub294 \ubc18\uba74, \uc18c\uc138\ud3ec\ud3d0\uc554\uc758 \uacbd\uc6b0 \uc815\ud655\ub3c4 \ub192\uc740 Biomarker\uc758 \ubd80\uc7ac\ub85c \ud45c\uc801 \ud56d\uc554\uc81c \uac1c\ubc1c\uc774 \uc5b4\ub824\uc6b4 \uc0c1\ud669\uc774\ub2e4.<\/p>\n
\uc5c5\ud14c\ub77c\ub294 PROTAC \uae30\uc220\uc744 \uc774\uc6a9\ud558\uc5ec \uc138\ud3ec\uc8fc\uae30(Cell cycle)\uac00 \ud65c\ubc1c\ud788 \uc9c4\ud589\ub418\ub294 \uc18c\uc138\ud3ec\ud3d0\uc554\uc5d0 \uc788\uc5b4 \uadfc\ubcf8\uc801\uc73c\ub85c \uacfc\ubc1c\ud604\ub418\ub294 PLK1 \ub2e8\ubc31\uc9c8\uc758 \uc9c1\uc811\ubd84\ud574\ub97c \ud1b5\ud574 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\uc8fc\uae30(Cell cycle)\ub97c \uba48\ucd94\uace0 \uc554\uc138\ud3ec \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\ub294 \uc2e0\uc57d\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4.<\/p>\n
PLK1\uc740 \uc138\ud3ec\uc8fc\uae30 G2, M\uae30\uc758 \uc138\ud3ec \ubd84\uc5f4\ud65c\ub3d9\uc744 \uad11\ubc94\uc704\ud558\uac8c \uad00\uc7a5\ud558\uba70 \uc138\ud3ec\ubd84\uc5f4\uc5d0 \uc788\uc5b4 \ud544\uc218\uc801\uc778 \uce74\uc774\ub124\uc774\uc988(Kinase) \ub2e8\ubc31\uc9c8\ub85c\uc11c \uc554\uc138\ud3ec\uc640 \uac19\uc774 \ud65c\ubc1c\ud558\uac8c \ubd84\uc5f4\ud558\ub294 \uc138\ud3ec\uc5d0 \uacfc\ubc1c\ud604\ub41c\ub2e4. \uadf8\uac04 \ubca0\ub9c1\uac70\uc789\uac94\ud558\uc784, \ub2e4\ucf00\ub2e4 \ub4f1 \ub9ce\uc740 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uc774 PLK1\uc744 \ud0c0\uac9f\ud558\ub294 \uc800\ubd84\uc790 \uc800\ud574\uc81c(Small molecule inhibitor) \uac1c\ubc1c\uc744 \uc2dc\ub3c4\ud558\uc600\uc73c\ub098, \ub300\ubd80\ubd84 \uc784\uc0c1\uc2dc\ud5d8 \ub2e8\uacc4\uc5d0\uc11c \uc6a9\ub7c9\uc81c\ud55c\ub3c5\uc131\ubc18\uc751(Dose-limiting toxicity, DLT)\uc73c\ub85c \uc778\ud574 \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \uc2e4\ud328\ud55c \ubc14 \uc788\ub2e4. \ud604\uc7ac PLK1 \ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c \ub610\ub294 \ubd84\ud574\ud558\ub294 \uae30\uc804\uc73c\ub85c \ud5c8\uac00 \uc2b9\uc778\ub41c \uc57d\ubb3c\uc740 \uc5c6\ub294 \uc0c1\ud669\uc774\ub2e4.<\/p>\n
\uc5c5\ud14c\ub77c\uc758 PLK1 \ubd84\ud574\uc57d\ubb3c\uc740 PLK1 \ub2e8\ubc31\uc9c8\uc758 \ub2e8\uc21c \uc800\ud574\ub97c \ud1b5\ud574 \uc57d\ud6a8\ub97c \ub3c4\ucd9c\ud558\uace0\uc790 \ud588\ub358 \uae30\uc874 \uc800\ubd84\uc790 \uc800\ud574\uc81c \ub300\ube44 \uc9c0\uc18d\uc801\uc73c\ub85c PLK1 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud560 \uc218 \uc788\ub294 PROTAC\uc758 \uc7a5\uc810\uc744 \ud65c\uc6a9\ud558\uc600\ub2e4. \uc0c1\ub300\uc801\uc73c\ub85c \ub0ae\uc740 \ud22c\uc5ec \ub18d\ub3c4\uc5d0\uc11c\ub3c4 \uc18c\uc138\ud3ec\ud3d0\uc554 \uc0ac\uba78\ud6a8\uacfc \ub3c4\ucd9c \ubc0f \uae30\uc874 \uc784\uc0c1 \uac1c\ubc1c \uc2e4\ud328\uc758 \uc8fc\uc694 \uc6d0\uc778\uc73c\ub85c \uc9c0\ubaa9\ub41c \uc6a9\ub7c9\uc81c\ud55c\ub3c5\uc131\ubc18\uc751(DLT)\uc744 \uadf9\ubcf5\ud55c \uac83\uc774 \ud2b9\uc9d5\uc774\ub2e4.<\/p>\n
\uc5c5\ud14c\ub77c\uc758 PLK1 \ubd84\ud574\uc57d\ubb3c\uc740 \u25b2PLK1\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554 \uc2e0\uc57d\uc774\uc790 \u25b2\ud504\ub85c\ud0c1(PROTAC) \uc5c5\uacc4\uc5d0\uc11c \uac1c\ubc1c \ub09c\uc774\ub3c4\uac00 \ub192\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub294 \uc138\ud3ec \uc8fc\uae30 (Cell cycle) \uad00\ub828 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \ucd5c\ucd08\uc758 \uc784\uc0c1 \ud30c\uc774\ud504\ub77c\uc778\uc774 \ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ud558\uace0 \uc788\ub2e4. \ub354\ubd88\uc5b4 \ud604\uc7ac \uc5c5\ud14c\ub77c\ub294 PLK1 \ubd84\ud574\uc57d\ubb3c\uacfc \uad00\ub828\ud558\uc5ec 41\uac74\uc758 \uad6d\ub0b4 \ubc0f PCT \ubb3c\uc9c8\ud2b9\ud5c8\ub97c \ucd9c\uc6d0\ud558\uc600\uace0, \uacc4\uc18d\ud574\uc11c \ud2b9\ud5c8 \uc7a5\ubcbd\uc744 \uad6c\ucd95\ud574 \ub098\uac00\uba74\uc11c PLK1 \ubd84\ud574 \uc601\uc5ed\uc5d0 \uc788\uc5b4\uc11c\ub294 \ud6c4\ubc1c\uc8fc\uc790 \uc9c4\uc785\uc744 \uc6d0\ucc9c \ucc28\ub2e8\ud558\uace0 First-in-class\uc758 \uc785\uc9c0\ub97c \ud655\uace0\ud788 \ud558\uace0\uc790 \ub178\ub825\ud558\uace0 \uc788\ub2e4.<\/p>\n
\uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\uc5d0 \uc120\uc815\ub41c PLK1 PROTAC \ud30c\uc774\ud504\ub77c\uc778 \uc678\uc5d0\ub3c4 \uc5c5\ud14c\ub77c\ub294 \ud504\ub85c\ud0c1(PROTAC) \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \ub2e4\uc218\uc758 \ud601\uc2e0\uc2e0\uc57d(First in class) \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc5f0\uad6c\uac1c\ubc1c \uc911\uc774\ub2e4. \uc62c\ud574 4\uc6d4\uc5d0\ub294 \uc720\ud55c\uc591\ud589\uacfc \ud2b9\uc815 \uc5fc\uc99d \uad00\ub828 \uc9c8\ud658 \ud0c0\uac9f \ubd84\ud574\uc57d\ubb3c\uc5d0 \uad00\ud55c \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \ubc0f \uae30\uc220\uc774\uc804\uacc4\uc57d\uc744 \uccb4\uacb0\ud55c \ubc14 \uc788\ub2e4. \ub610\ud55c, \ud504\ub85c\ud0c1(PROTAC) \uc5c5\uacc4\uc758 \ud654\ub450\ub85c \ub5a0\uc624\ub974\uace0 \uc788\ub294 \uc2e0\uaddc E3 \ub9ac\uac00\uc544\uc81c(E3L) \uac1c\ubc1c\uc744 \uc704\ud55c \uc720\ub9dd E3L \uc120\uc815 \uae30\uc220(UPPGRADERTM<\/sup>) \ubc0f \ud574\ub2f9 E3L\uc5d0 \uae30\ub2a5\ud558\ub294 \uc800\ubd84\uc790\ubb3c\uc9c8 \ubc1c\uad74 \ud50c\ub7ab\ud3fc(UPPBEATTM<\/sup>)\uacfc \uac19\uc740 \ub3c5\uc790\uc801\uc778 \ud50c\ub7ab\ud3fc \uae30\uc220\uc744 \uad6c\ucd95\ud558\uc5ec \ub2e4\uc218\uc758 Novel E3L \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc5f0\uad6c\u2219\uac1c\ubc1c \uc911\uc5d0 \uc788\ub2e4.\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\ub294 \u201c\uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\ub2e8\uc774 \uc5c5\ud14c\ub77c\uc758 PLK1 \ud6c4\ubcf4\ubb3c\uc9c8\uc758 \uac00\ub2a5\uc131\uc744 \ud3c9\uac00\ud574\uc900 \uac83\uc5d0 \ub300\ud574 \uac10\uc0ac\ub4dc\ub9b0\ub2e4.\u201d\uba70, \u201c\uc62c\ud574 \ucd08\ubd80\ud130 \ub2e4\uc218\uc758 \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac\ub4e4\uacfc PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c\uacfc \uad00\ub828\ub41c \ub17c\uc758\ub97c \uc9c4\ud589\ud558\uace0 \uc788\ub294 \ub9cc\ud07c \uc870\uae30 \uae30\uc220\uc218\ucd9c \ubc0f \uc784\uc0c1 \uc9c4\uc785\uc73c\ub85c \ubcf4\ub2f5 \ub4dc\ub9ac\uaca0\ub2e4.\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":" \uc5c5\ud14c\ub77c, \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub4e4\uacfc \ube44\uc784\uc0c1\uc744 \uc9c4\ud589 \uc911\uc778 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud56d\uc554\uc2e0\uc57d\uc778 PLK1 \ubd84\ud574\uc57d\ubb3c\uc758 \uae30\uc220\uc218\ucd9c \ub17c\uc758 \uc608\uc815 \uc5c5\ud14c\ub77c, PLK1\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35433"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35433"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35433\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}