{"id":35436,"date":"2024-02-26T17:59:38","date_gmt":"2024-02-26T08:59:38","guid":{"rendered":"https:\/\/uppthera.cafe24.com\/?p=35436"},"modified":"2024-02-26T17:59:38","modified_gmt":"2024-02-26T08:59:38","slug":"%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%e3%88%9c%ec%97%85%ed%85%8c%eb%9d%bc-%e3%88%9c%eb%b3%b4%eb%a0%b9%ea%b3%bc-%eb%8b%a4%eb%b0%9c%ec%84%b1%ea%b3%a8%ec%88%98%ec%a2%85multiple-myeloma-mm","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2024\/02\/26\/%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%e3%88%9c%ec%97%85%ed%85%8c%eb%9d%bc-%e3%88%9c%eb%b3%b4%eb%a0%b9%ea%b3%bc-%eb%8b%a4%eb%b0%9c%ec%84%b1%ea%b3%a8%ec%88%98%ec%a2%85multiple-myeloma-mm\/","title":{"rendered":"[\ubcf4\ub3c4 \uc790\ub8cc] \u321c\uc5c5\ud14c\ub77c, \u321c\ubcf4\ub839\uacfc \ub2e4\ubc1c\uc131\uace8\uc218\uc885(Multiple Myeloma, MM) \uce58\ub8cc\uc81c \uc2e0\uc57d \u201c\uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \ubc0f \uc870\uae30 \uae30\uc220\uc218\ucd9c\uc5d0 \uad00\ud55c \ud611\uc5c5 \uacc4\uc57d\u201d \uccb4\uacb0"},"content":{"rendered":"

\u321c\uc5c5\ud14c\ub77c \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc \ubaa9\uc801\uc758 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc870\uae30 \uc81c3<\/strong>\uc790 \uae30\uc220\uc218\ucd9c\uc744 \uc704\ud55c \ud611\uc5c5 \uacc4\uc57d<\/strong><\/span><\/p>\n

\uae30\uc874\uc5d0 Undruggable \ud588\ub358 \uc720\ub9dd \uc57d\ubb3c \ud0c0\uac9f\uc5d0 \ub300\ud574, \ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574 \ubaa8\ub2ec\ub9ac\ud2f0\ub97c \ud1b5\ud55c First-in-class \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc870\uae30 \uc0ac\uc5c5\ud654\ub97c \uc704\ud55c \ud611\uc5c5<\/strong><\/span><\/p>\n

\"\"<\/p>\n

\u321c\uc5c5\ud14c\ub77c\u00a0\ucd5c\uc2dc\uc6b0\u00a0\ub300\ud45c\uc774\uc0ac(\uc67c\ucabd)\uc640\u00a0\u321c\ubcf4\ub839\u00a0\uc7a5\ub450\ud604\u00a0\ub300\ud45c\uc774\uc0ac(\uc624\ub978\ucabd)\uac00\u00a0\uacc4\uc57d\u00a0\uccb4\uacb0\u00a0\uc774\ud6c4\u00a0\uae30\ub150\uc0ac\uc9c4\uc744\u00a0\ucd2c\uc601\ud558\uace0\u00a0\uc788\ub2e4. (\uc0ac\uc9c4\uc81c\uacf5=\u321c\uc5c5\ud14c\ub77c)<\/span><\/p>\n

 <\/p>\n

\ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220(Targeted protein degradation, TPD) \uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 (\uc8fc)\uc5c5\ud14c\ub77c (\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0)\ub294 \uc9c0\ub09c\ud574 23\uc77c \uad6d\ub0b4 \ud56d\uc554\uc81c \ubd84\uc57c\uc758 \uc120\ub450\uc8fc\uc790\uc778 \u321c\ubcf4\ub839 (\ub300\ud45c\uc774\uc0ac \uae40\uc815\uade0, \uc7a5\ub450\ud604)\uacfc \ub2e4\ubc1c\uc131\uace8\uc218\uc885(Multiple Myeloma, MM) \uc2e0\uc57d\ud6c4\ubcf4\ubb3c\uc9c8\uc758 \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \ubc0f \uc870\uae30 \uc0ac\uc5c5\ud654\ub97c \uc704\ud55c \ud611\uc5c5 \uacc4\uc57d\uc744 \uccb4\uacb0\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/span><\/p>\n

\ubcf8 \ud611\uc5c5 \uacc4\uc57d\uc740 \uc5c5\ud14c\ub77c\uc758 \ucd08\uae30 \ub514\uc2a4\ucee4\ubc84\ub9ac \ub2e8\uacc4 \ud30c\uc774\ud504\ub77c\uc778\uc778 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud654\ud569\ubb3c\uc744 \ub2e4\uad6d\uc801 \uc81c\uc57d\uc0ac\ub97c \ud3ec\ud568\ud55c \ub77c\uc774\uc120\uc2dc\uc5d0\uac8c \uc870\uae30\uc5d0 \uae30\uc220\uc218\ucd9c \ud558\ub294 \uac83\uc744 \ud575\uc2ec \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\ub2e4. \uc774\ub97c \uc704\ud574 \uc5c5\ud14c\ub77c\ub294 \uc2e0\uc18d\ud55c \ube44\uc784\uc0c1 \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c\uc744 \uc704\ud55c \uc5f0\uad6c\uac1c\ubc1c\uc5d0 \uc9d1\uc911\ud558\ub294 \ud55c\ud3b8, \ubcf4\ub839\uc740 \ucd08\uae30 \uc5f0\uad6c\uac1c\ubc1c \ub2e8\uacc4\ubd80\ud130 \uc120\uc81c\uc801\uc778 \uc0ac\uc5c5\uac1c\ubc1c \ud65c\ub3d9\uc744 \uc218\ud589\ud558\ub294 \ud615\ud0dc\ub85c \ud611\uc5c5\ud560 \uc608\uc815\uc774\ub2e4.<\/span><\/p>\n

\uc5c5\ud14c\ub77c\ub294 \ubcf8 \uacc4\uc57d\uc744 \ud1b5\ud574 \ubcf4\ub839\uc73c\ub85c\ubd80\ud130 \uc77c\uc815 \uacc4\uc57d\uae08\uc744 \uc218\ub839\ud558\uace0 \ud6c4\ubcf4\ubb3c\uc9c8 \ub3c4\ucd9c \uc2dc\uc810\uae4c\uc9c0 \ud2b9\uc815 \uc131\uacfc \ub2ec\uc131 \uc2dc \ub9c8\uc77c\uc2a4\ud1a4\uc744 \uc218\ucde8\ud560 \uc608\uc815\uc774\ub2e4. \ubcf8 \ub2e8\ubc31\uc9c8 \ubd84\ud574\ud654\ud569\ubb3c\uc774 \uc81c3\uc790 \uae30\uc220\uc218\ucd9c\uc744 \ub2ec\uc131\ud558\uac8c \ub418\uba74, \ubcf4\ub839\uc740 \ubc1c\uc0dd\ud558\ub294 \uc218\uc775\uc744 \uc77c\uc815 \ube44\uc728\ub85c \ubc30\ubd84 \ubc1b\uace0 \uc0c1\uc5c5\ud654 \uc131\uacf5 \uc2dc \ub3c5\uc810\uc801 \uad6d\ub0b4 \ud310\uad8c\uc744 \ubcf4\uc720\ud55c\ub2e4. \uc591\uc0ac \uacc4\uc57d\uc5d0 \ub530\ub978 \uacc4\uc57d\uae08 \ubc0f \ub9c8\uc77c\uc2a4\ud1a4\uc758 \uaddc\ubaa8\ub294 \ube44\uacf5\uac1c\ud558\uae30\ub85c \ud558\uc600\ub2e4.<\/span><\/p>\n

\ub2e4\ubc1c\uc131\uace8\uc218\uc885\uc740 \ud615\uc9c8\uc138\ud3ec(plasma cell)\uac00 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uc99d\uc2dd\ud558\uc5ec \uc804\uc2e0\uc5d0 \ub2e4\ubc1c\uc131\uc73c\ub85c \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\ub294 \uc9c8\ubcd1\uc73c\ub85c \ubc31\ud608\ubcd1, \ub9bc\ud504\uc885\uacfc \ud568\uaed8 3\ub300 \ud608\uc561\uc554\uc73c\ub85c \ubd84\ub958\ub41c\ub2e4. \uc778\uad6c \uc99d\uac00 \ubc0f \uace0\ub839\ud654\ub85c \uc778\ud574 \uc720\ubcd1\ud658\uc790 \uc218\uac00 \uc9c0\uc18d\uc801\uc73c\ub85c \uc99d\uac00\ud558\ub294 \ucd94\uc138\uc5d0 \uc788\uc73c\uba70 \uc7ac\ubc1c\ub960\uc774 \ub9e4\uc6b0 \ub192\uc544 \uc0ac\uc2e4\uc0c1 \uc644\uce58\uc758 \uac1c\ub150\uc774 \uc5c6\ub294 \ub09c\uce58\uc554\uc774\ub2e4. \ud604\uc7ac \ub808\ube14\ub9ac\ubbf8\ub4dc(Lenalidomide), \ub2e4\uc798\ub809\uc2a4(Daratumumab), \ud3ec\ub9d0\ub9ac\uc2a4\ud2b8(Pomalidomide) \ub4f1\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc81c \ubc0f \uce58\ub8cc \uc635\uc158\ub4e4\uc774 \uc874\uc7ac\ud558\uace0 \uc788\uc73c\ub098 \uc7ac\ubc1c\ub960\uc774 \ub9e4\uc6b0 \ub192\uace0 \uadf8\uc5d0 \ub530\ub978 \uae30\uc874 \uce58\ub8cc\uc81c \ubd88\uc751\uc131 \ud658\uc790\ub4e4\uc774 \ub9ce\uc740 \ub2e4\ubc1c\uc131\uace8\uc218\uc885\uc758 \ud2b9\uc131\uc744 \uac10\uc548\ud560 \ub54c \ub354 \ub9ce\uc740 \uc2e0\uc57d\uacfc \uce58\ub8cc \uc635\uc158\ub4e4\uc774 \ud544\uc694\ud558\ub2e4\ub294 \uac83\uc774 \uc784\uc0c1\uc758\ub4e4\uc758 \uc911\ub860\uc774\ub2e4.\u00a0<\/span><\/p>\n

\ud574\ub2f9 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8\uc740 \uc774\ubbf8 \ub9ce\uc740 \uc120\ud589\uc5f0\uad6c\ub4e4\uc744 \ud1b5\ud574 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc5d0 \ub9e4\uc6b0 \uc720\ub9dd\ud55c \uc57d\ubb3c \ud0c0\uac9f\uc73c\ub85c \uc798 \uc54c\ub824\uc838 \uc788\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ub2e8\ubc31\uc9c8 \ud06c\uae30\uac00 \uc791\uace0, \ubc14\uc778\ub529 \ud3ec\ucf13(Binding pocket)\uc774 \uc801\uc73c\uba70, Co-factor \ub4e4\uc774 \ub9ce\uc544 \uae30\uc874 \uc800\ubd84\uc790\uc800\ud574\uc81c(small molecule inhibitor) \ubaa8\ub2ec\ub9ac\ud2f0\ub85c\ub294 \uc2e0\uc57d\uac1c\ubc1c\uc774 \uc5b4\ub824\uc6e0\ub358 \ub300\ud45c\uc801\uc778 Undruggable \ud0c0\uac9f\uc774\uc5c8\ub2e4.<\/span><\/p>\n

\ud558\uc9c0\ub9cc \uccb4\ub0b4\uc758 \uc720\ube44\ud034\ud2f4 \ud504\ub85c\ud14c\uc544\uc880 \uc2dc\uc2a4\ud15c(Ubiquitin Proteasome System, UPS)\uc744 \ud1b5\ud574 \uc9c8\ubcd1\uc6d0\uc778 \ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \ubd84\ud574\ud558\ub294 PROTAC\uc744 \ud3ec\ud568\ud55c \ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220\uc740 \uc5b4\ub5a4 \ubc29\uc2dd\uc73c\ub85c\ub4e0 \uc9c8\ubcd1\uc6d0\uc778 \ub2e8\ubc31\uc9c8\uc5d0 \uc720\ube44\ud034\ud2f4\ud654(Ubiquitination)\ub9cc \uc2dc\ucf1c\uc904 \uc218 \uc788\uc73c\uba74 \ubd84\ud574\uac00 \uac00\ub2a5\ud55c \ubc14, \uc774\ub7ec\ud55c \ud2b9\uc7a5\uc810\uc5d0 \uae30\ubc18\ud558\uc5ec \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8\uc744 \uc5b5\uc81c(\ubd84\ud574)\ud558\ub294 \uc2e0\uc57d \uac1c\ubc1c\uc774 \uac00\ub2a5\ud558\ub2e4. \uc5c5\ud14c\ub77c\ub294 \ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220\uc744 \uc774\uc6a9\ud558\uc5ec, B\uc138\ud3ec\uac00 \ud56d\uccb4\ub97c \uc0dd\uc0b0\ud558\ub294 \ud615\uc9c8\uc138\ud3ec\ub85c \ubd84\ud654\ud558\ub294\ub370 \uc788\uc5b4 \ud575\uc2ec\uc801 \uc5ed\ud560\uc744 \ud558\ub294 \ud2b9\uc815 \uc804\uc0ac\uc778\uc790(Transcription factor) \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \uc2e0\uc57d\ud6c4\ubcf4\ubb3c\uc9c8\uc744 \uac1c\ubc1c \uc911\uc5d0 \uc788\ub2e4.<\/span><\/p>\n

\uc5c5\ud14c\ub77c\uac00 \ud0c0\uac9f\ud558\ub294 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8\uc740 \ub300\ud45c\uc801\uc778 Undruggable(\uc57d\ubb3c\uce58\ub8cc \ubd88\uac00\ub2a5) \ud0c0\uac9f\uc774\uae30 \ub54c\ubb38\uc5d0 \ud574\ub2f9 \ub2e8\ubc31\uc9c8\uc5d0 \uacb0\ud569\ud558\ub294 \uc800\ud574\uc81c\ub098 \ubc14\uc778\ub354 \ud654\ud569\ubb3c\uc774 \uac1c\ubc1c\ub41c \uc774\ub825\uc774 \uc804\ubb34\ud558\ub2e4. \ub530\ub77c\uc11c \uc5c5\ud14c\ub77c\ub294 \uc678\ubd80 \ud30c\ud2b8\ub108\ub97c \ud1b5\ud55c \ub378 \uc2a4\ud06c\ub9ac\ub2dd (DELs, DNA encoded library screening) \ubc0f \uc790\uccb4\uc801\uc778 chemoproteomics \uae30\ubc18 covalent binder \uc2a4\ud06c\ub9ac\ub2dd \ud50c\ub7ab\ud3fc(UPPBEAT\u2122)\uc744 \ud1b5\ud574 \ud574\ub2f9 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8\uc5d0 \uacb0\ud569\ud558\ub294 Novel hit binder \ud654\ud569\ubb3c\uc744 \ubc1c\uad74\ud558\uace0 \uc774\ub97c \ud1b5\ud574 \ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574 \ud654\ud569\ubb3c\uc744 \uac1c\ubc1c \uc911\uc5d0 \uc788\ub2e4. \u00a0<\/span><\/p>\n

\ubcf4\ub839\uc758 \uacbd\uc6b0 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc81c\uc640 \uad00\ub828\ud558\uc5ec \uad6d\ub0b4 \uc2dc\ud310 \uc911\uc778 \ub808\ube14\ub9ac\ud0a8\ucea1\uc290(\uc131\ubd84\uba85: Lenalidomide), \ubca8\ud0a8\uc8fc (\uc131\ubd84\uba85: Bortezomib) \uc640 \uc2a4\ud398\uc778 \uc81c\uc57d\uae30\uc5c5 \ud30c\ub9c8\ub9c8\u793e(PharmaMar)\uc5d0\uc11c \uad6d\ub0b4 \ub3c4\uc785\ud558\uc5ec \uc0c1\uc5c5\ud654 \ub3c5\uc810\uad8c\uc744 \ud655\ubcf4\ud558\uace0 \uc788\ub294 \uc544\ud50c\ub9ac\ub518(\uc131\ubd84\uba85: Plitidepsin) \ub97c \ubcf4\uc720\ud558\uace0 \uc788\ub2e4. \ub610\ud55c 2021\ub144 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc81c\ub85c \uc0ac\uc6a9\ub418\ub294 \ud3ec\ub9d0\ub9ac\uc2a4\ud2b8(\uc131\ubd84\uba85: Pomalidomide)\uc5d0 \ub300\ud55c \ud2b9\ud5c8 \ud68c\ud53c \uc131\uacf5\uc73c\ub85c 2023\ub144 \uc911 \uc81c\ub124\ub9ad \ud5c8\uac00 \uc2e0\uccad\uc774 \uac00\ub2a5\ud55c \ub9cc\ud07c, \ud5a5\ud6c4 \ubcf4\ub839\uc740 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 1\ucc28\ubd80\ud130 3\ucc28 \ud45c\uc900\uce58\ub8cc\uc81c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ub2e4\uc591\ud55c \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc81c \ud3ec\ud2b8\ud3f4\ub9ac\uc624\ub97c \uad6c\ucd95\ud558\uac8c \ub420 \uc608\uc815\uc774\ub2e4. \ubcf4\ub839\uc740 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc81c \uc2dc\ud310 \uacbd\ud5d8\uacfc \uad00\ub828 \uc804\ubb38\uac00\/\uc784\uc0c1\uc758 \ub124\ud2b8\uc6cc\ud06c\ub97c \ud1b5\ud574 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ubc0f \uad00\ub828 \uce58\ub8cc\uc81c \uc2dc\uc7a5\uc5d0 \ub300\ud55c \ud48d\ubd80\ud55c \uc774\ud574\uc640 \uc804\ubb38\uc131\uc744 \ud655\ubcf4\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 \ubcf8 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud654\ud569\ubb3c\uc5d0 \ub300\ud55c \uc120\uc81c\uc801\uc778 \uc0ac\uc5c5\uac1c\ubc1c \ud65c\ub3d9\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc218\ud589\ud560 \uc608\uc815\uc774\ub2e4. \u00a0\u00a0\u00a0<\/span><\/p>\n

\ubcf4\ub839 \uc7a5\ub450\ud604 \ub300\ud45c\ub294 “\uc5c5\ud14c\ub77c\uc758 R&D \uc5ed\ub7c9\uacfc \ubcf4\ub839\uc758 \ud56d\uc554\uc81c \uc0ac\uc5c5 \ub178\ud558\uc6b0\uac00 \ub9cc\ub098 \uc88b\uc740 \uc131\uacfc\uac00 \uae30\ub300\ub41c\ub2e4”\uace0 \ubc1d\ud788\uba70, “\ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790\ub4e4\uc5d0\uac8c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\uc635\uc158\uc73c\ub85c \ud76c\ub9dd\uc744 \ub4dc\ub9b4 \uc218 \uc788\ub3c4\ub85d, \uc2e0\uc57d \uc870\uae30 \uac1c\ubc1c\uc5d0 \uc9d1\uc911\ud574 \ub098\uac08 \uac83”\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/span><\/p>\n

\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\ub294 \u201c\uad6d\ub0b4 \ud56d\uc554\uc81c \ubd84\uc57c\uc758 \uc120\ub450\uc8fc\uc790\uc778 \ubcf4\ub839\uacfc \ud611\uc5c5\uc744 \uc9c4\ud589\ud560 \uc218 \uc788\uac8c \ub418\uc5b4 \ub9e4\uc6b0 \uae30\uc058\uac8c \uc0dd\uac01\ud558\uba70 \uc591\uc0ac\uac00 \uac00\uc9c4 \uae30\uc220 \ubc0f \uc0ac\uc5c5\ud654 \uc5ed\ub7c9\uc758 \uacb0\ud569\uc744 \ud1b5\ud574 \uc870\uc18d\ud788 \uc5f0\uad6c\uac1c\ubc1c \ubc0f \uc0ac\uc5c5\ud654 \uc131\uacfc\ub97c \ub2ec\uc131 \ud560 \uc218 \uc788\ub3c4\ub85d \ub178\ub825\ud558\uaca0\ub2e4.\u201c\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/span><\/p>\n\n\n\n
\n

\u321c\uc5c5\ud14c\ub77c (UPPTHERA Inc.)\uc5d0 \ub300\ud558\uc5ec<\/strong><\/span><\/p>\n

\uc5c5\ud14c\ub77c\ub294\u00a0PROTAC(Proteolysis Targeting Chimera,\u00a0\ud45c\uc801\ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\uc220) \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \uc2e0\uc57d\ubb3c\uc9c8\uc744 \ubc1c\uad74\ud558\uc5ec \ube44\uc784\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70, PROTAC \uae30\uc220\uc5d0 \ub300\ud55c \ub3c5\uc790\uc801\uc778 \ud50c\ub7ab\ud3fc \uae30\uc220\uae4c\uc9c0 \ubcf4\uc720\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

PROTAC\u00a0\uae30\uc220\uc740 \uc138\ud3ec \ub0b4 \ub178\ud654, \uacfc\ubc1c\ud604 \ub2e8\ubc31\uc9c8 \ub4f1 \uc798\ubabb \ub9cc\ub4e4\uc5b4\uc9c4 \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 UPP(Ubiquitin-Proteasome Pathway)\ub97c \uc778\uc704\uc801\uc73c\ub85c \uadf9\ub300\ud654 \uc2dc\ud0a4\ub294 \ucc28\uc138\ub300 \uc2e0\uc57d\uac1c\ubc1c \uae30\uc220\uc774\ub2e4. \uc5c5\ud14c\ub77c\ub294 \uc138\ud3ec\uc8fc\uae30 G2, M\uae30\uc758 \uc138\ud3ec \ubd84\uc5f4\ud65c\ub3d9\uc744 \uad11\ubc94\uc704\ud558\uac8c \uad00\uc7a5\ud558\ub294 PLK1\uc744 \ubd84\ud574\ud558\ub294 \uc2e0\uc57d\ubb3c\uc9c8\uc744 \ubc1c\uad74\ud558\uc5ec \ud604\uc7ac \uc18c\uc138\ud3ec\ud3d0\uc554\uc744 \uc801\uc751\uc99d\uc73c\ub85c \ube44\uc784\uc0bc\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70, 2023\ub144 \uc784\uc0c1 1\uc0c1\uc744 \uc9c4\ud589\ud560 \uacc4\ud68d\uc774\ub2e4.<\/span><\/p>\n

\ud574\ub2f9 \ud30c\uc774\ud504\ub77c\uc778 \uc678\uc5d0\ub3c4 \ud604\uc7ac 6\uac1c\uc758 PROTAC \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\uc744 \uc5f0\uad6c \uac1c\ubc1c \uc911\uc774\uba70, 2022\ub144 04\uc6d4 \uc720\ud55c\uc591\ud589\uacfc \uc5fc\uc99d\uc720\ubc1c \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \uc2e0\uc57d\uc5d0 \ub300\ud55c \uae30\uc220\ub77c\uc774\uc120\uc2a4 \ubc0f \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c \uacc4\uc57d\uc744 \uccb4\uacb0\ud55c \ubc14 \uc788\ub2e4.\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n","protected":false},"excerpt":{"rendered":"

\u321c\uc5c5\ud14c\ub77c \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc \ubaa9\uc801\uc758 \uc804\uc0ac\uc778\uc790 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc870\uae30 \uc81c3\uc790 \uae30\uc220\uc218\ucd9c\uc744 \uc704\ud55c \ud611\uc5c5 \uacc4\uc57d \uae30\uc874\uc5d0 Undruggable \ud588\ub358 \uc720\ub9dd \uc57d\ubb3c…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35436"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35436"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35436\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}