{"id":35440,"date":"2024-02-26T18:01:21","date_gmt":"2024-02-26T09:01:21","guid":{"rendered":"https:\/\/uppthera.cafe24.com\/?p=35440"},"modified":"2024-02-26T18:01:21","modified_gmt":"2024-02-26T09:01:21","slug":"%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-100%ec%96%b5%ec%9b%90-%ea%b7%9c%eb%aa%a8%ec%9d%98-%ed%95%b4%ec%99%b8-%ed%88%ac%ec%9e%90-%ec%9c%a0%ec%b9%98","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2024\/02\/26\/%eb%b3%b4%eb%8f%84-%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-100%ec%96%b5%ec%9b%90-%ea%b7%9c%eb%aa%a8%ec%9d%98-%ed%95%b4%ec%99%b8-%ed%88%ac%ec%9e%90-%ec%9c%a0%ec%b9%98\/","title":{"rendered":"[\ubcf4\ub3c4 \uc790\ub8cc] \uc5c5\ud14c\ub77c, 100\uc5b5\uc6d0 \uaddc\ubaa8\uc758 \ud574\uc678 \ud22c\uc790 \uc720\uce58"},"content":{"rendered":"

– \uc5c5\ud14c\ub77c, \ubc14\uc774\uc624\ubd84\uc57c \uc804\ubb38 \ud574\uc678\ud22c\uc790\uc790\uc778 YuanBio Venture Capital\ub85c\ubd80\ud130 100\uc5b5\uc6d0 \uaddc\ubaa8\uc758 \uc2dc\ub9ac\uc988B-\ube0c\ub9bf\uc9c0 \ud574\uc678\ud22c\uc790 \uc720\uce58<\/strong><\/span><\/p>\n

– \ud22c\uc790\uc720\uce58 \uc774\ud6c4 PLK1 \ubd84\ud574 \ud56d\uc554\uc2e0\uc57d\uc758 \uc784\uc0c1\uc9c4\uc785 \uc5f0\uad6c \ubc0f \ud6c4\uc18d \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778 \ucd5c\uc801\ud654\uc5f0\uad6c, Novel E3 ligase \ud50c\ub7ab\ud3fc R&D \uac00\uc18d\ud654 \uacc4\ud68d<\/strong><\/span><\/p>\n

\n

\ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220(Targeted protein degradation, TPD) \uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 \u321c\uc5c5\ud14c\ub77c (\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0)\ub294 \uc911\uad6d \uc18c\uc7ac\uc758 \uc720\uba85 \ubc14\uc774\uc624\uc804\ubb38 VC\uc778 YuanBio Venture Capital\ub85c\ubd80\ud130 100\uc5b5\uc6d0 \uaddc\ubaa8\uc758 \uc2dc\ub9ac\uc988B-\ube0c\ub9bf\uc9c0 \ud22c\uc790\ub97c \uc720\uce58\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/span><\/p>\n

\uc5c5\ud14c\ub77c\ub294 TPD \uae30\uc220\uc744 \uc774\uc6a9\ud558\uc5ec \u201c\ub2ff\uc9c0 \uc54a\ub294 \ud658\uc790\uc5d0\uac8c \ud76c\ub9dd\uc744 \uc5f0\uacb0\ud558\uace0 \uac00\ub2a5\uc131\uc744 \ud569\uc131\ud558\uc5ec \uc808\ub9dd\uc744 \ubd84\ud574\ud55c\ub2e4.\u201d \ube44\uc804\uc73c\ub85c \ub73b\uc744 \ubaa8\uc544 2018\ub144\uc5d0 \uc124\ub9bd\ub41c \uc774\ud6c4 \u25b22019\ub144 Pre-Series \uc57d 26\uc5b5\uc6d0, \u25b22020\ub144 Series A \uc57d 127\uc5b5\uc6d0, \u25b22022\ub144 Series B \uc57d 280\uc5b5\uc6d0 \ud22c\uc790 \uc720\uce58 \uc774\ud6c4 \uc57d 1\ub144\ub9cc\uc5d0 Series B-\ube0c\ub9bf\uc9c0 100\uc5b5\uc6d0\uc744 \ucd94\uac00\ub85c \uc720\uce58\ud558\uba70 \ucd1d 530\uc5b5\uc6d0\uc758 \ud22c\uc790\uae08\uc744 \uc720\uce58\ud588\ub2e4. \ub610\ud55c, \ub300\uc2e0\uc99d\uad8c\uacfc \ub300\ud45c \uc8fc\uad00\uc0ac \uacc4\uc57d\uc744 \uccb4\uacb0\ud558\uace0 \uae30\uc5c5\uacf5\uac1c(IPO)\ub97c \uc704\ud55c \uc0c1\uc7a5\uc744 \uc900\ube44\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

\uc774\ubc88 \ube0c\ub9bf\uc9c0 \ud22c\uc790\uc5d0 \ub2e8\ub3c5\uc73c\ub85c \ucc38\uc5ec\ud55c YuanBio Venture Capital\uc740 2013\ub144\uc5d0 \uc124\ub9bd\ub418\uc5b4 \ucd08\uae30 \ubc0f \uc131\uc7a5 \ub2e8\uacc4 \uae30\uc5c5\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\ub294 \uc911\uad6d \ub0b4\uc5d0\uc11c 10\ub300 \ubca4\ucc98 \uce90\ud53c\ud0c8\ub85c \uc131\uc7a5\ud55c \ubc14\uc774\uc624&\ud5ec\uc2a4\ucf00\uc5b4 \uc804\ubb38\ud22c\uc790 \ud68c\uc0ac\uc774\ub2e4. \ud2b9\ud788, \ud604\uc7ac\uae4c\uc9c0 \uc57d 170\uac1c\uc0ac\uc5d0 \ud22c\uc790\ub97c \uc9d1\ud589\ud588\uc73c\uba70, 19\uac1c\uc758 \ud3ec\ud2b8\ud3f4\ub9ac\uc624 \uae30\uc5c5\uc774 \ub098\uc2a4\ub2e5 \ubc0f \ud64d\ucf69 \uac70\ub798\uc18c\uc5d0 \uc0c1\uc7a5\ub418\uba70 \uc0c1\ub2f9\ud55c \ud22c\uc790 \uc218\uc775\uc744 \ucc3d\ucd9c\ud558\uc5ec \uc911\uad6d\uc5d0\uc11c \ucd5c\uace0\uc758 \ubc14\uc774\uc624 \uc804\ubb38 VC\ub85c \uc778\uc815\ubc1b\uace0 \uc788\ub2e4. \ud604\uc7ac YuanBio\uc758 \uc6b4\uc6a9\uc790\uc0b0\uc740 \uc57d 13\uc5b5 \ub2ec\ub7ec(\ud55c\ud654\ub85c \uc57d 1.7\uc870\uc6d0)\uc5d0 \ub2ec\ud558\ub294 \ub300\ud615 \ubca4\ucc98 \uce90\ud53c\ud0c8\uc0ac\uc774\ub2e4. \u00a0<\/span><\/p>\n

YuanBio\ub294 \uc5c5\ud14c\ub77c\uac00 \uac1c\ubc1c\ud558\uace0 \uc788\ub294 TPD\uae30\ubc18 PLK1 \ubd84\ud574 \ud56d\uc554 \uc2e0\uc57d\uc758 \uae00\ub85c\ubc8c \uae30\uc220\uc774\uc804 \uac00\ub2a5\uc131 \ubc0f \ud6c4\uc18d Degrader \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\ub4e4\uc758 \ub3c5\ucc3d\uc131, \uc0c8\ub85c\uc6b4(Novel) E3 ligase \ud50c\ub7ab\ud3fc\uae30\uc220\uc758 \ud655\uc7a5\uc131\uc5d0 \uae30\ub300\ub97c \uac16\uace0 \ud22c\uc790\ud55c \uac83\uc73c\ub85c \uc54c\ub824\uc84c\ub2e4.<\/span><\/p>\n

\uc5c5\ud14c\ub77c\ub294 PLK1\uc744 \ubd84\ud574\ud558\ub294 \ud56d\uc554\uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\uc740 2022\ub144 9\uc6d4 \uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\uc5d0 \uc120\uc815\ub418\uc5b4 \ud604\uc7ac \ubbf8\uad6d FDA \uc784\uc0c1\uc2dc\ud5d8 \uc9c4\uc785\uc744 \uc704\ud55c \ud5c8\uac00 \ube44\uc784\uc0c1 \uc5f0\uad6c\ub97c \uc218\ud589 \uc911\uc774\ub2e4. \ub610\ud55c, AURKA \ub2e8\ubc31\uc9c8\uc744 \ubd84\ud574\ud558\ub294 \ud56d\uc554\uc2e0\uc57d \ud6c4\uc18d \ud30c\uc774\ud504\ub77c\uc778\uc774 2023\ub144 \uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\uc5d0 \uc120\uc815\ub418\uc5c8\ub2e4. 2\uac1c \uacfc\uc81c \ubaa8\ub450 \uc138\ud3ec \ubd84\uc5f4 \uc8fc\uae30\uc5d0 \uad00\ub828\ub41c \ub2e8\ubc31\uc9c8\uc744 \ud0c0\ucf13\ud558\ub294 \ud56d\uc554 \uc2e0\uc57d\uc73c\ub85c PLK1 Degrader \uc5f0\uad6c\uac1c\ubc1c \uacbd\ud5d8\uc744 \ubc14\ud0d5\uc73c\ub85c AURKA Degrader\uc758 \ubb3c\uc9c8 \ucd5c\uc801\ud654 \ubc0f \ube44\uc784\uc0c1\uc5f0\uad6c\ub97c \uae30\uc874 \ub300\ube44 \ube60\ub974\uac8c \uc9c4\uc785\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

\ub610\ud55c, \ud6c4\uc18d \uc2e0\uc57d\ud30c\uc774\ud504\ub77c\uc778\ub4e4\uc758 \uacbd\uc6b0 \u321c\uc720\ud55c\uc591\ud589, \u321c\ubcf4\ub839\uacfc\uc758 \uacf5\ub3d9\uc5f0\uad6c\uac1c\ubc1c\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70 \ub098\uc544\uac00 \ud68c\uc0ac\uac00 \uc790\uccb4\uc801\uc73c\ub85c \uad6c\ucd95\ud55c UPPGRADERTM<\/sup>(TPD \ub85c \uc811\uadfc\uc774 \uc720\ub9dd\ud55c Novel E3 ligase \uc120\uc815)\uc640 UPPBEATTM<\/sup>(\uc120\uc815\ub41c E3 ligase\uc5d0 \uae30\ub2a5\ud558\ub294 \uc2e0\uaddc binder\ubc1c\uad74) \uae30\uc220\ub4e4\uc744 \ubc14\ud0d5\uc73c\ub85c Novel E3 ligase\uc5d0 \uae30\ub2a5\ud558\ub294 \ud50c\ub7ab\ud3fc \ubc14\uc778\ub354 \ubc1c\uad74\uc5d0 \uad00\ud55c \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uace0 \uc788\ub2e4.<\/span><\/p>\n

YuanBio Venture Capital\uc758 Jacky Chen\u00a0\ub300\ud45c\ub294\u00a0“\uc5c5\ud14c\ub77c\ub294 \uc804 \uc138\uacc4\uc801\uc73c\ub85c TPD \ubd84\uc57c\uc5d0\uc11c \uc120\ub3c4\uc801\uc778 \uc704\uce58\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\uc73c\uba70, \ud601\uc2e0\uc801\uc774\uace0 \ucc28\ubcc4\ud654\ub41c \uc5f0\uad6c\uac1c\ubc1c \ub2a5\ub825\uc744 \ub192\uc774 \ud3c9\uac00\ud55c\ub2e4.\u201d\uba70, \u201cPLK1 Degrader\ub294 TPD\uc758 \uc7a5\uc810\uc744 \ud1b5\ud574 PLK1 \uc800\ubd84\uc790 \uc5b5\uc81c\uc81c\uc758 \uace0\uc720\ud55c \ub2e8\uc810\uc744 \uadf9\ubcf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub418\uba70, \ud68c\uc0ac\uac00 \uad6c\ucd95\ud55c \ud50c\ub7ab\ud3fc \uae30\uc220\uc740 \uc0c8\ub85c\uc6b4 E3 ligase\uc744 \ubc1c\uacac\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc774 \uc788\uc5b4 \ud5a5\ud6c4 \ud30c\uc774\ud504\ub77c\uc778 \ud655\uc7a5\uc5d0 \ubd84\uba85\ud55c \uc774\uc810\uc774 \uc788\ub2e4.”\uace0 \ubc1d\ud614\ub2e4.\u00a0<\/span><\/p>\n

\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\ub294 \u201c\ud22c\uc790 \uc720\uce58\uc790\uae08\uc740 PLK1 Degrader \ud30c\uc774\ud504\ub77c\uc778\uc758 \uc784\uc0c1\uc5f0\uad6c \ubc0f \ud6c4\uc18d \uc2e0\uc57d\ud30c\uc774\ud504\ub77c\uc778\ub4e4\uc758 \ucd5c\uc801\ud654\uc5f0\uad6c, Novel E3 ligase \ud50c\ub7ab\ud3fc \ud30c\uc774\ud504\ub77c\uc778\uc5f0\uad6c \ub4f1\uc5d0 \ud22c\uc785\ud560 \uacc4\ud68d\uc774\ub2e4.\u201d\ub77c\uba70, \u201c\ub2e8\uae30\uc801\uc73c\ub85c\ub294 PLK1 Degrader \ud30c\uc774\ud504\ub77c\uc778\uc758 \uae00\ub85c\ubc8c \uae30\uc220\uc774\uc804\uc744 \ud1b5\ud574 \uc0ac\uc5c5\ud654 \uc131\uacfc\ub97c \ub2ec\uc131\ud558\uace0, \uc7a5\uae30\uc801\uc73c\ub85c\ub294 TPD\uc5c5\uacc4\uc758 \ud575\uc2ec \uc131\uc7a5 \ub3d9\ub825\uc73c\ub85c \uc790\ub9ac\uc7a1\uac8c \ub420 Novel E3 ligase \ud50c\ub7ab\ud3fc \ubc14\uc778\ub354\uc5d0 \uad00\ud55c \ud22c\uc790\ub97c \uc120\uc81c\uc801\uc73c\ub85c \uc2e4\uc2dc\ud558\uc5ec \uae00\ub85c\ubc8c TPD\uc804\ubb38 \uc2e0\uc57d\uac1c\ubc1c \ud68c\uc0ac\ub85c \uc131\uc7a5\ud574 \ub098\uac08 \uacc4\ud68d\uc774\ub2e4.\u201d\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/span><\/p>\n

\n\n\n\n
\n

YuanBio Venture Capital\u00a0<\/strong>\uc5d0 \ub300\ud558\uc5ec<\/strong><\/span><\/p>\n

\uc911\uad6d\uc758 YuanBio Venture Capital(\uc774\ud558 YuanBio)\uc740 2013\ub144\uc5d0 \uc124\ub9bd\ub418\uc5b4 \ubc14\uc774\uc624 \ubc0f \ud5ec\uc2a4\ucf00\uc5b4 \ubd84\uc57c\uc5d0\uc11c 10\ub300 \ubca4\ucc98 \uce90\ud53c\ud0c8\ub85c \uc131\uc7a5\ud55c \uc911\uad6d \ub0b4 \uc720\uba85 VC\ub85c \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4. YuanBio\ub294 \ucd08\uae30 \ubc0f \uc131\uc7a5 \ub2e8\uacc4\uc758 \uae30\uc5c5\uc5d0 \uc8fc\ub85c \ud22c\uc790\ud558\uba70, \uc0dd\uba85\uacf5\ud559, \uc758\ub8cc\uae30\uae30, \uc758\ub8cc \uc11c\ube44\uc2a4 \ub4f1 \ub2e4\uc591\ud55c \ubd84\uc57c\uc5d0 170\uc5ec \uac1c \uc774\uc0c1\uc758 \uae30\uc5c5\uc5d0 \uae00\ub85c\ubc8c\ud558\uac8c \ud22c\uc790\ub97c \uc644\ub8cc\ud558\uc600\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 \uc6b0\uc218\ud55c \uc131\uacfc\ub97c \uc5bb\uc5b4\ub0c8\uc2b5\ub2c8\ub2e4.<\/span><\/p>\n

\ud2b9\ud788, 19\uac1c\uc758 \ud3ec\ud2b8\ud3f4\ub9ac\uc624 \uae30\uc5c5\uc774 \ub098\uc2a4\ub2e5 \ubc0f \ud64d\ucf69\uac70\ub798\uc18c\uc5d0 \uc0c1\uc7a5\ub418\uba70 \uc0c1\ub2f9\ud55c \ud22c\uc790 \uc218\uc775\uc744 \ucc3d\ucd9c\ud558\uc5ec YuanBio\ub294 \uc911\uad6d\uc5d0\uc11c \ucd5c\uace0\uc758 \ubc14\uc774\uc624 \uc804\ubb38 VC\ub85c \uc778\uc815\ubc1b\uc544\uc654\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc131\uacfc\ub85c \uc778\ud574 \uc5ec\ub7ec \ucc28\ub840 \uc218\uc0c1\uc744 \uacbd\ud5d8\ud558\uba70, YuanBio\ub294 \ucd5c\uace0\uc758 \uc785\uc9c0\ub97c \ud655\uace0\ud788 \ud558\uc600\uc2b5\ub2c8\ub2e4. \ud604\uc7ac YuanBio\uc758 \uc6b4\uc6a9\uc790\uc0b0\uc740 \uc57d 1.3\uc5b5 \ub2ec\ub7ec(\ud55c\ud654\ub85c \uc57d 1.7\uc870\uc6d0)\uc5d0 \ub2ec\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/span><\/p>\n

\ud648\ud398\uc774\uc9c0 \ub9c1\ud06c :\u00a0<\/em>http:\/\/en.bioventure.com.cn\/<\/em><\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n","protected":false},"excerpt":{"rendered":"

– \uc5c5\ud14c\ub77c, \ubc14\uc774\uc624\ubd84\uc57c \uc804\ubb38 \ud574\uc678\ud22c\uc790\uc790\uc778 YuanBio Venture Capital\ub85c\ubd80\ud130 100\uc5b5\uc6d0 \uaddc\ubaa8\uc758 \uc2dc\ub9ac\uc988B-\ube0c\ub9bf\uc9c0 \ud574\uc678\ud22c\uc790 \uc720\uce58 – \ud22c\uc790\uc720\uce58 \uc774\ud6c4 PLK1 \ubd84\ud574 \ud56d\uc554\uc2e0\uc57d\uc758 \uc784\uc0c1\uc9c4\uc785…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35440"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35440"}],"version-history":[{"count":0,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35440\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}