{"id":35693,"date":"2025-10-20T09:18:14","date_gmt":"2025-10-20T09:18:14","guid":{"rendered":"https:\/\/www.uppthera.com\/ko\/?p=35693"},"modified":"2025-10-29T08:19:27","modified_gmt":"2025-10-29T08:19:27","slug":"%eb%b3%b4%eb%8f%84%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-sclc%ec%86%8c%ec%84%b8%ed%8f%ac%ed%8f%90%ec%95%94-%eb%8c%80%ec%83%81-tpd-%ec%b9%98%eb%a3%8c%ec%a0%9c-%e7%be%8e-%ec%9e%84%ec%83%81","status":"publish","type":"post","link":"https:\/\/www.uppthera.com\/ko\/2025\/10\/20\/%eb%b3%b4%eb%8f%84%ec%9e%90%eb%a3%8c-%ec%97%85%ed%85%8c%eb%9d%bc-sclc%ec%86%8c%ec%84%b8%ed%8f%ac%ed%8f%90%ec%95%94-%eb%8c%80%ec%83%81-tpd-%ec%b9%98%eb%a3%8c%ec%a0%9c-%e7%be%8e-%ec%9e%84%ec%83%81\/","title":{"rendered":"[\ubcf4\ub3c4\uc790\ub8cc] \uc5c5\ud14c\ub77c, SCLC(\uc18c\uc138\ud3ec\ud3d0\uc554) \ub300\uc0c1 TPD \uce58\ub8cc\uc81c \u7f8e \uc784\uc0c1 1\/2a\uc0c1 \uc9c4\uc785"},"content":{"rendered":"<p><strong>&#8211; \uc5c5\ud14c\ub77c, \uae00\ub85c\ubc8c \ucd5c\ucd08\ub85c PLK1\uc744 \ud0c0\uae43\ud558\ub294 TPD \uc2e0\uc57d\ud6c4\ubcf4\ubb3c\uc9c8 SCLC(\uc18c\uc138\ud3ec\ud3d0\uc554) \uc784\uc0c1 1\/2a \uc9c4\uc785<\/strong><\/p>\n<p>\ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220(Targeted protein degradation, TPD) \uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5 \uc5c5\ud14c\ub77c (\ub300\ud45c\uc774\uc0ac \ucd5c\uc2dc\uc6b0)\ub294 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc73c\ub85c\ubd80\ud130 PLK1 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574\uae30\ubc18(TPD) \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8 \u2018UP1002\u2019\uc758 \uc18c\uc138\ud3ec\ud3d0\uc554(SCLC) \ub300\uc0c1 \uc784\uc0c1 1\/2a\uc0c1 \uc2dc\ud5d8\uacc4\ud68d(IND) \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\uc774\ubc88 \uc2b9\uc778\uc740 PLK1\uc744 \ud0c0\uae43\uc73c\ub85c \ud558\ub294 TPD \uacc4\uc5f4 \uc2e0\uc57d\uc73c\ub85c\ub294 \uae00\ub85c\ubc8c \ucd5c\ucd08\uc758 \uc784\uc0c1 \uc9c4\uc785 \uc0ac\ub840\ub85c, \uc5c5\ud14c\ub77c\uc758 \ub3c5\uc790\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \uae30\uc220\ub825\uacfc \uae00\ub85c\ubc8c \uacbd\uc7c1\ub825\uc744 \uc785\uc99d\ud558\ub294 \uc131\uacfc\ub85c \ud3c9\uac00\ub41c\ub2e4. \ub0b4\ub144\uc5d0\ub294 \uad6d\ub0b4\uc5d0\uc11c\ub3c4 IND \uc2b9\uc778 \uc808\ucc28\ub97c \uc9c4\ud589\ud574 \ubcf8\uaca9\uc801\uc73c\ub85c \u2018UP1002\u2019\uc758 \uae00\ub85c\ubc8c \uc784\uc0c1\uc2dc\ud5d8\uc744 \ud655\ub300\ud574 \ub098\uac08 \uacc4\ud68d\uc774\ub2e4.<\/p>\n<p>\uc774\ubc88\uc5d0 \uc2b9\uc778\ub41c \uc784\uc0c1\uc740 1\/2a\uc0c1 \ubcf5\ud569 \ub514\uc790\uc778\uc73c\ub85c, \ucd08\uae30 \uc6a9\ub7c9 \uc99d\ub7c9(dose escalation)\uc744 \ud1b5\ud574 \uc548\uc804\uc131\uacfc \ub0b4\uc57d\uc131\uc744 \ud655\uc778\ud55c \ub4a4, \ud655\uc7a5 \ucf54\ud638\ud2b8(expansion cohort)\ub97c \ud1b5\ud574 \ud6a8\ub2a5 \uc9c0\ud45c\ub97c \ud3c9\uac00\ud558\ub294 \ub2e8\uacc4\ub85c \uc9c4\ud589\ub41c\ub2e4. \uc5c5\ud14c\ub77c\ub294 \ubbf8\uad6d \ub0b4 30~60\uba85 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ub0b4\ub144\ubd80\ud130 \uccab \ud658\uc790 \ud22c\uc5ec\ub97c \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\uc73c\uba70, \ud5a5\ud6c4 \uacb0\uacfc\uc5d0 \ub530\ub77c \ub2e4\ub978 \uace0\ud615\uc554 \uc801\uc751\uc99d\uc73c\ub85c\uc758 \ud655\uc7a5\ub3c4 \uac80\ud1a0\ud560 \uacc4\ud68d\uc774\ub2e4.<\/p>\n<p>\uc18c\uc138\ud3ec\ud3d0\uc554(SCLC)\uc740 \uc9c0\ub09c \uc218\uc2ed \ub144 \uac04 \uc2e0\uc57d \uac1c\ubc1c\uc774 \ud0c0 \uc554\uc885\uc5d0 \ube44\ud574 \ub09c\uc774\ub3c4\uac00 \ub9e4\uc6b0 \ub192\uc740 \uc554\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc5c8\uace0, \ucd5c\uadfc \uc2b9\uc778\ub41c \uc57d\ubb3c\ub4e4 \ub610\ud55c \uc0dd\uc874\uae30\uac04 \uc5f0\uc7a5 \ub4f1\uc758 \ud56d\uc554 \ud6a8\ub825\uc774 \uc81c\ud55c\uc801\uc778 \uc0c1\ud669\uc774\ub2e4<\/p>\n<p>\ub610\ud55c, \uc885\uc591\uc758 \uc804\uc774 \uc18d\ub3c4\uac00 \ube60\ub974\uace0 \uc7ac\ubc1c\ub960\uc774 \ub192\uc544 5\ub144 \uc0dd\uc874\uc728\uc774 7% \ubbf8\ub9cc \uc218\uc900\uc73c\ub85c \ub9e4\uc6b0 \ub0ae\uc740 \ub09c\uce58\uc554\uc774\ub2e4. \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\uc758 \uacbd\uc6b0 \uc2e0\ub8b0\ub3c4 \ub192\uc740 Biomarker\ub97c \uae30\ubc18\uc73c\ub85c \ub2e4\uc218\uc758 \ud45c\uc801 \ud56d\uc554\uc81c \uac1c\ubc1c\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub294 \ubc18\uba74, \uc18c\uc138\ud3ec\ud3d0\uc554\uc758 \uacbd\uc6b0 \uc815\ud655\ub3c4 \ub192\uc740 Biomarker\uc758 \ubd80\uc7ac\ub85c \ud45c\uc801 \ud56d\uc554\uc81c \uac1c\ubc1c\uc774 \uc5b4\ub824\uc6b4 \uc0c1\ud669\uc774\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\ub294 \uc774\ub7ec\ud55c \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uae30 \uc704\ud574 TPD \uae30\uc220\uc744 \ud65c\uc6a9, \uc138\ud3ec \ubd84\uc5f4 \uc870\uc808\uc758 \ud575\uc2ec \ub2e8\ubc31\uc9c8\uc778 PLK1(Polo-like kinase 1)\uc744 \uc9c1\uc811 \ubd84\ud574\ud558\ub294 \uc2e0\uc57d \ud6c4\ubcf4 \u2018UP1002\u2019\ub97c \uac1c\ubc1c \uc911\uc774\ub2e4. PLK1\uc740 \uc138\ud3ec\uc8fc\uae30(G2\/M\uae30)\uc5d0\uc11c \uc138\ud3ec\ubd84\uc5f4\uc744 \uc870\uc808\ud558\ub294 \ud544\uc218 \ub2e8\ubc31\uc9c8(Kinase)\ub85c, \uc554\uc138\ud3ec\ucc98\ub7fc \ube60\ub974\uac8c \uc99d\uc2dd\ud558\ub294 \uc138\ud3ec\uc5d0\uc11c \uacfc\ubc1c\ud604\ub41c\ub2e4. \uadf8\uac04 \ubca0\ub9c1\uac70\uc789\uac94\ud558\uc784, \ub2e4\ucf00\ub2e4 \ub4f1 \ub2e4\uc218\uc758 \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac\uac00 PLK1 \uc800\ud574\uc81c(small molecule inhibitor)\ub97c \uac1c\ubc1c\ud588\uc73c\ub098, \ub300\ubd80\ubd84 \uc784\uc0c1 \ub2e8\uacc4\uc5d0\uc11c \uc6a9\ub7c9\uc81c\ud55c\ub3c5\uc131\ubc18\uc751(DLT)\uc73c\ub85c \uc911\ub2e8\ub41c \ubc14 \uc788\ub2e4. \ud604\uc7ac\uae4c\uc9c0 PLK1\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uac70\ub098 \ubd84\ud574\ud558\ub294 \uae30\uc804\uc73c\ub85c \ud5c8\uac00 \uc2b9\uc778\ub41c \uc57d\ubb3c\uc740 \uc5c6\ub294 \uc0c1\ud669\uc774\ub2e4.<\/p>\n<p>UP1002\ub294 PLK1 \ub2e8\ubc31\uc9c8\uc744 \uc9c1\uc811 \ubd84\ud574\ud568\uc73c\ub85c\uc368 \uae30\uc874 \uc800\ud574\uc81c\ubcf4\ub2e4 \ub0ae\uc740 \ub18d\ub3c4\uc5d0\uc11c\ub3c4 \ud56d\uc554 \ud6a8\uacfc\ub97c \uc720\ub3c4\ud558\uace0, \uc6a9\ub7c9\uc81c\ud55c\ub3c5\uc131\ubc18\uc751(DLT) \ubb38\uc81c\ub97c \uadfc\ubcf8\uc801\uc73c\ub85c \uadf9\ubcf5\ud55c \uac83\uc774 \ud2b9\uc9d5\uc774\ub2e4. \uc774 \uae30\uc804\uc740 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\uc8fc\uae30 \uc790\uccb4\ub97c \uba48\ucd94\uac8c \ud574 \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\ub294 \uc0c8\ub85c\uc6b4 \uc811\uadfc\ubc95\uc73c\ub85c, \uc18c\uc138\ud3ec\ud3d0\uc554\ucc98\ub7fc \uc138\ud3ec \uc99d\uc2dd\uc774 \ube60\ub978 \uc554\uc885\uc5d0\uc11c \uce58\ub8cc \ud328\ub7ec\ub2e4\uc784 \uc804\ud658\uc744 \uc774\ub04c \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c\uc758 UP1002(PLK1)\uc740 \uadf8 \ud601\uc2e0\uc131\uacfc \uae30\uc220\ub825\uc744 \uc778\uc815\ubc1b\uc544 2022\ub144 \uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5(KDDF)\u00a0\uacfc\uc81c\ub85c \uc120\uc815\ub418\uc5b4 \uc9c0\uc6d0\uc744 \ubc1b\uc558\uc73c\uba70, KDDF \uacfc\uc81c \ub0b4 \uae00\ub85c\ubc8c RA \uc9c0\uc6d0\uc0ac\uc5c5\uc744 \uae30\ubc18\uc73c\ub85c \ud050\ubca0\uc2a4\ud2b8\ubc14\uc774\uc624(QubeST Bio), KCRN Research\u00a0\ub4f1 \uae00\ub85c\ubc8c \uc784\uc0c1 \uc804\ubb38\uae30\uad00\uacfc \ud611\ub825\ud558\uba70 \uae00\ub85c\ubc8c \uc784\uc0c1 \uac1c\ubc1c \uc804\ub7b5\uc744 \uc218\ub9bd\ud574\uc654\ub2e4.<\/p>\n<p>UP1002\ub294 \u25b2PLK1\uc744 \ubd84\ud574\ud558\ub294 \ucd5c\ucd08\uc758 (First-in class) \ud56d\uc554 \uc2e0\uc57d\uc774\uc790 \u25b2TPD \uc5c5\uacc4\uc5d0\uc11c \uac1c\ubc1c \ub09c\uc774\ub3c4\uac00 \ub192\uc740 \uc138\ud3ec\uc8fc\uae30 (Cell cycle) \uad00\ub828 \ub2e8\ubc31\uc9c8\uc744 \ud45c\uc801\ud558\ub294 \ucd5c\ucd08\uc758 \uc784\uc0c1 \ud30c\uc774\ud504\ub77c\uc778\uc73c\ub85c \ud3c9\uac00\ubc1b\uace0 \uc788\ub2e4. \ub610\ud55c, \uc5c5\ud14c\ub77c\ub294 UP1002\uc640 \uad00\ub828\ud558\uc5ec 82\uac74\uc758 \uad6d\ub0b4\uc678 \ud2b9\ud5c8\ub97c \ucd9c\uc6d0\ud558\uc600\uc73c\uba70, \uc774 \uc911 19\uac74\uc774 \ub4f1\ub85d \uc644\ub8cc\ub418\uc5c8\ub2e4. \ud68c\uc0ac\ub294 \uc9c0\uc18d\uc801\uc73c\ub85c \ud2b9\ud5c8 \ud3ec\ud2b8\ud3f4\ub9ac\uc624\ub97c \uac15\ud654\ud558\uace0 \ud2b9\ud5c8 \uc7a5\ubcbd\uc744 \uad6c\ucd95\ud574 \ub098\uac00\uba74\uc11c PLK1 \ubd84\ud574 \uc601\uc5ed\uc5d0 \uc788\uc5b4\uc11c\ub294 \ud6c4\ubc1c\uc8fc\uc790 \uc9c4\uc785\uc744 \uc6d0\ucc9c \ucc28\ub2e8\ud558\uace0 First mover\ub85c\uc11c\uc758 \uc785\uc9c0\ub97c \ud655\uace0\ud788 \ud560 \uacc4\ud68d\uc774\ub2e4.<\/p>\n<p>\uc5c5\ud14c\ub77c \ucd5c\uc2dc\uc6b0 \ub300\ud45c\ub294 \u201c\uc774\ubc88 FDA IND \uc2b9\uc778\uc740 \uc5c5\ud14c\ub77c\uc758 \ub3c5\uc790\uc801 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \uae30\uc220\ub825\uacfc \uae00\ub85c\ubc8c \uac1c\ubc1c \uc5ed\ub7c9\uc744 \uacf5\uc2dd\uc801\uc73c\ub85c \uc778\uc815\ubc1b\uc740 \uc131\uacfc\u201d\ub77c\uba70, \u201c\uc784\uc0c1 \uc131\uacfc\ub97c \ud1b5\ud574 \uc18c\uc138\ud3ec\ud3d0\uc554 \ud658\uc790\ub4e4\uc5d0\uac8c \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uc2dc\ud558\uace0, TPD \ubd84\uc57c\uc5d0\uc11c \uae00\ub85c\ubc8c \uacbd\uc7c1\ub825\uc744 \uac15\ud654\ud574 \ub098\uac00\uaca0\ub2e4.\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; \uc5c5\ud14c\ub77c, \uae00\ub85c\ubc8c \ucd5c\ucd08\ub85c PLK1\uc744 \ud0c0\uae43\ud558\ub294 TPD \uc2e0\uc57d\ud6c4\ubcf4\ubb3c\uc9c8 SCLC(\uc18c\uc138\ud3ec\ud3d0\uc554) \uc784\uc0c1 1\/2a \uc9c4\uc785 \ud45c\uc801\ub2e8\ubc31\uc9c8\ubd84\ud574\uae30\uc220(Targeted protein degradation, TPD) \uae30\ubc18 \ud601\uc2e0 \uc2e0\uc57d\uac1c\ubc1c \uc804\ubb38\uae30\uc5c5&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35693"}],"collection":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/comments?post=35693"}],"version-history":[{"count":2,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35693\/revisions"}],"predecessor-version":[{"id":35695,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/posts\/35693\/revisions\/35695"}],"wp:attachment":[{"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/media?parent=35693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/categories?post=35693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uppthera.com\/ko\/wp-json\/wp\/v2\/tags?post=35693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}