PipeLine

Targeted Protein Degradation

A New Way to Treat Disease
Uppthera is a clinical stage biopharmaceutical company developing novel protein degrader therapeutics to treat disease in powerful new ways, which harness the body’s natural protein degradation system to selectively degrade disease causing proteins with the goal of completely removing them from the body. Uppthera is driven to invent transformative medicines for a wide variety of diseases where traditional drug modalities have failed to sufficiently unlock the appropriate biological solution.

Novel E3L Platform

A Powerful Drug Discovery Engine

Uppthera has developed a proprietary targeted protein degradation platform called Pegasus which enables the design of highly selective small molecule protein degraders – heterobifunctional molecules with potent activity against disease-causing proteins. Thanks to our Whole Body E3 Ligase Atlas, Pegasus is expanding the universe of potential disease targets and possible treatments.

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