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Pipeline

We develop degrader pipelines with a robust scientific rationale and a clear market goal

  • Despite the challenges, our focus lies not on fast-following targets but on previously undruggable or unconquered targets with the potential to be first-in-class drugs.
  • We decide to pursure a specific degrader pipeline only when we determine that the TPD modality is the best option over other drug madalities for addressing a specific disease-causing protein, considering its ralate biology and pathology.

Degrader pipelines

  • Pipeline
  • Drug target
  • Indication
  • Target ID,
    PoC study
  • Hit
  • Lead
  • Candidate
  • CMC, IND-
    Enabling study
  • Phase 1
UP1002PLK1Onco
UP1009Cell cycle related proteinOnco
UP1006Cell death related proteinOnco
UP1010IRF4Onco
UP1007Inflammation related proteinCNS