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UPPTHERA develops innovative drugs employing TPD science

UPS(Ubiquitin Proteasome System) is an intracellular protein degradation pathway which breaks about 80% of intracellular proteins : TPD(Targeted Protein Degradation) is a novel drug modality degrading disease-causing proteins by harnessing the UPS.

Degraders have competitive edges in solving unmet needs which have not been solved by traditional drug modalities

Small Molecule Inhibitor

SM inhibitor could be developed only for a protein that possesses binding pocket with an active site

(15% of total disease-causing protein)

'Inhibition' of disease-causing proteins
Low target selectivity / Off-target issue
1 drug inhibits 1 protein

(Occupancy-driven MoA)

VS

Degrader

Degrader could degrade a disease-causing protein as long as it binds the protein in any manner to make it ubquitinated, regardless of presence of binding pocket in the protein
'Degradation' of disease-causing proteins
Enhance target selectivity
1 drug degrades multiple proteins

(Event-driven MoA)