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SpeedUPP™ Platform

SpeedUPP™

Our degrader pipeline development platform

SpeedUPP™

UPPTHERA's PROTAC Pipeline development platform (Rapid Lead generation platform)

High-throughput screening
  • Luciferase based Live cell Assay platform (max. 2,000 compounds / week)
  • In-house capability to develop cell lines for the live cell assay per pipelines & purposes

Quantitative Proteomics assay in house for a preliminary off-target profilling

Early in vivo test
  • Early mouse, rat PK screening in house - PD/Efficacy screening in house
  • Test in vitro ADME/T for a few selected cmpds

Further Design for PROTAC with advanced drug-like properties based on the early in vivo test results

Effective PROTAC Design / Rapid Synthesis
  • Knowledge + Computational chem. based design
  • Proprietary linker database
  • Proprietary CRBN/VHL ligand database
  • Major intermediates building block in stock
PROTAC Hit to Candidate : 2 ~ 2.5yrs
Early lead cmpds
Massive in vivo tests / Lead Opt.
Candidate cmpd
Features of SpeedUPP™
  • Enhance a chance to obtain lead cmpd. with high drug-like properties
  • Develop PROTAC pipeline in a fast manner